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The objective of the study was to determine the frequency, evolution and pathogenicity of anti-SPCA1 and anti-M3AchR autoantibodies in pemphigus. Anti-SPCA1 and anti-M3AchR IgG were detected in almost one-third of sera from patients with pemphigus. We demonstrated their in vitro pathogenic activity, alone or in combination. Anti-SPCA1 and anti-M3AchR autoantibodies were associated with a higher risk of relapse and may help clinicians in patient management.<\/jats:p>","DOI":"10.1093\/bjd\/ljag093","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:21:48Z","timestamp":1773058908000},"page":"1182-1184","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and pathogenicity of anti-SPCA1 and anti-M3AchR autoantibodies in pemphigus"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-010X","authenticated-orcid":false,"given":"Billal","family":"Tedbirt","sequence":"first","affiliation":[{"name":"University of Rouen Normandie, Inserm, Normandie University, PANTHER UMR 1234, CHU Rouen, Department of Dermatology , Rouen 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Normandie, Normandie University, PRIMACEN , Rouen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1055-106X","authenticated-orcid":false,"given":"Leopoldine","family":"Lebourgeois","sequence":"additional","affiliation":[{"name":"University of Rouen Normandie, Inserm, Normandie University, PANTHER UMR 1234 , Rouen ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-2033","authenticated-orcid":false,"given":"Vivien","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"University of Rouen Normandie, Inserm, Normandie University, PANTHER UMR 1234, CHU Rouen, Department of Dermatology , Rouen 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