{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:52:56Z","timestamp":1782233576472,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea government"},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-NR077086"],"award-info":[{"award-number":["RS-2023-NR077086"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2023-KH141286"],"award-info":[{"award-number":["RS-2023-KH141286"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo is a chronic depigmentation disorder caused by selective melanocyte loss. Autoreactive CD8+ T cells are known contributors, but impaired melanocyte\u2013keratinocyte adhesion due to E-cadherin dysfunction has also been implicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the key adhesion molecules mediating melanocyte\u2013basement membrane interactions and to investigate their modulation in response to vitiligo-associated factors, including interferon (IFN)-\u03b3 and mechanical stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary human epidermal melanocytes and ex vivo human skin tissues were exposed to IFN-\u03b3 and mechanical stress. To identify key molecules involved in melanocyte adhesion, we integrated RNA sequencing data from prior studies with antibody array profiling. The involvement of focal adhesion-associated proteins in melanocyte\u2013basement membrane attachment was further assessed by confocal imaging of skin from patients with vitiligo, revealing a reduction in these molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Exposure to IFN-\u03b3 and mechanical stress reduced focal adhesion kinase (FAK) and integrin \u03b21 (ITG\u03b21) expression in melanocytes and ex vivo human skin, increasing melanocyte detachment. Both molecules were also decreased in basal keratinocytes and melanocytes from the skin of patients with vitiligo compared with healthy controls. Pretreatment with the Janus kinase inhibitor baricitinib, used in vitiligo therapy, reduced melanocyte detachment through a cathepsin L (CTSL)-dependent mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IFN-\u03b3 and mechanical stress contribute to melanocyte detachment from the basement membrane via CTSL, FAK and ITG\u03b21 regulation. These findings highlight the importance of melanocyte-basement membrane adhesion in vitiligo pathogenesis and offer insight into the Koebner phenomenon in disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag113","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:22:47Z","timestamp":1774869767000},"page":"109-121","source":"Crossref","is-referenced-by-count":1,"title":["Unanchored by two hits: interferon-\u03b3 and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-2652","authenticated-orcid":false,"given":"Eun Jung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Joo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seohyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-ting","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Human\u2013Environment Interface Biology, Medical Research Center, Seoul National University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinwon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u00a0Jeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Ram","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, CHA University , Pocheon ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal Mohammed","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Imam Abdulrahman Bin Faisal University ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, CHA University , Pocheon ,","place":["Korea"]},{"name":"Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine , Seongnam ,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinu","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University , Incheon 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