{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:55:53Z","timestamp":1782233753813,"version":"3.54.5"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"grants from the Liaison Committee for Education"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is recognized as a systemic inflammatory disease associated with metabolic dysregulation. Understanding these metabolic changes may reveal biomarkers to elucidate disease mechanisms and predict comorbidities. While previous studies have identified psoriasis-associated metabolites, findings are often limited by sample sizes and lack validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify circulating metabolites associated with psoriasis, including disease severity and psoriatic arthritis. Further, we investigated whether the metabolic signature was disease-specific compared with other immune-mediated inflammatory diseases (IMIDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a cross-sectional analysis of 470 352 White\/European individuals from the UK Biobank (n = 453 428) and HUNT (n = 16 924). Nuclear magnetic resonance spectroscopy was used to quantify metabolite levels, covering lipoprotein fractions and subfractions, fatty acids and small-molecular metabolites. For each metabolite, we performed multivariable linear regression adjusting for age, sex, body mass index, smoking status and use of lipid-lowering medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The metabolomic profile of psoriasis was largely consistent across the two populations. In the model adjusted for age and sex, 123 metabolic measures were associated with psoriasis. After full adjustment, only glycoprotein acetyls remained associated with psoriasis [coefficient 95% confidence interval (CI) 0.09 (0.07\u20130.11) in UK Biobank and 0.11 (95% CI 0.06\u20130.17) in HUNT]. In HUNT, severe psoriasis exhibited more pronounced metabolic alterations compared with nonsevere psoriasis. Across both populations, phenylalanine levels were highly elevated in psoriatic arthritis compared with cutaneous psoriasis [0.44 (95% CI 0.29\u20130.60) in UK Biobank and 0.47 (95% CI 0.2\u20130.67) in HUNT]. In comparisons across IMIDs, atopic dermatitis and cutaneous-limited psoriasis exhibited milder metabolic alterations, and psoriasis in HUNT showed a distinct lipoprotein profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large-scale study confirms metabolic alterations in individuals with psoriasis and highlights phenylalanine as a potential biomarker for joint involvement in psoriasis. The distinct metabolomic profile of psoriasis relative to other IMIDs suggests a potentially unique systemic profile. These findings offer a foundation for advancing biomarker research and mechanistic studies for psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag116","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:22:50Z","timestamp":1774869770000},"page":"68-78","source":"Crossref","is-referenced-by-count":0,"title":["Circulating metabolites associated with\u00a0psoriasis in the UK Biobank and the HUNT Study: a\u00a0cross-sectional study of 470 352 participants"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8710-4418","authenticated-orcid":false,"given":"Alya G A","family":"Arham","sequence":"first","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-6210","authenticated-orcid":false,"given":"Abhibhav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent F","family":"Thomas","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"BioCore - Bioinformatics Core Facility, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-9455","authenticated-orcid":false,"given":"Ravi","family":"Ramessur","sequence":"additional","affiliation":[{"name":"St John\u2019s Institute of Dermatology, Faculty of Life Sciences and Medicine, School of Basic and Medical Biosciences, King\u2019s College London , London ,","place":["UK"]},{"name":"Department of Dermatology and Center for Clinical Sciences in Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-8043","authenticated-orcid":false,"given":"Julia","family":"Debik","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-9156","authenticated-orcid":false,"given":"Marion","family":"Denos","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9992-8663","authenticated-orcid":false,"given":"Mari","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Department of Rheumatology, St. Olavs Hospital, Trondheim University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-3889","authenticated-orcid":false,"given":"Vibeke","family":"Videm","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Department of Immunology and Transfusion Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-0889","authenticated-orcid":false,"given":"Lavinia","family":"Paternoster","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit, University of Bristol , Bristol ,","place":["UK"]},{"name":"NIHR Bristol Biomedical Research Centre, University Hospital Bristol and Weston NHS Foundation Trust and University of Bristol , Bristol ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-1144","authenticated-orcid":false,"given":"Catherine","family":"Smith","sequence":"additional","affiliation":[{"name":"St John\u2019s Institute of Dermatology, Faculty of Life Sciences and Medicine, School of Basic and Medical Biosciences, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-2101","authenticated-orcid":false,"given":"Bj\u00f8rn\u00a0O","family":"\u00c5svold","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-8824","authenticated-orcid":false,"given":"Guro F","family":"Giske\u00f8deg\u00e5rd","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-1059","authenticated-orcid":false,"given":"Ben M","family":"Brumpton","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"HUNT Research Centre, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology , Levanger ,","place":["Norway"]},{"name":"Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital , Trondheim ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-6551","authenticated-orcid":false,"given":"Mari","family":"L\u00f8set","sequence":"additional","affiliation":[{"name":"HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology , Trondheim ,","place":["Norway"]},{"name":"Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital , Trondheim 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