{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:26:03Z","timestamp":1786749963714,"version":"build-2736575974"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Psoriasis Council"},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:p>We used Mendelian randomization to investigate whether genetic proxies of glucagon-like peptide-1 receptor (GLP1R) expression are associated with risk of psoriasis and psoriatic arthritis (PsA). Higher GLP1R expression was associated with reduced susceptibility to psoriasis and PsA, independent of metabolic traits, while no risk-reducing effects were observed for other immune-mediated inflammatory diseases. These results highlight a disease-specific association between GLP1 pathway activity and psoriatic disease.<\/jats:p>","DOI":"10.1093\/bjd\/ljag163","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:31:50Z","timestamp":1777116710000},"page":"184-186","source":"Crossref","is-referenced-by-count":2,"title":["Genetic proxies of glucagon-like peptide-1 receptor expression are associated with lower risk of psoriasis and psoriatic arthritis"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-9455","authenticated-orcid":false,"given":"Ravi","family":"Ramessur","sequence":"first","affiliation":[{"name":"Department of Dermatology and Center for Clinical Sciences in Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]},{"name":"St John\u2019s Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8710-4418","authenticated-orcid":false,"given":"Alya G A","family":"Arham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Saklatvala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent F","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben M","family":"Brumpton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-3889","authenticated-orcid":false,"given":"Vibeke","family":"Videm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Olav","family":"\u00c5svold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Clinical Sciences in Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-9564","authenticated-orcid":false,"given":"Dokyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H","family":"Smith","sequence":"additional","affiliation":[{"name":"St John\u2019s Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0A","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"L\u00f8set","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Clinical Sciences in Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]},{"name":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026062312163763000_ljag163-B1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41573-025-01183-8","article-title":"GLP-1-based therapies for diabetes, obesity and beyond","volume":"24","author":"Drucker","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"2026062312163763000_ljag163-B2","first-page":"1148","article-title":"Efficacy of glucagon-like peptide-1 receptor agonists for psoriasis: an updated systematic review and meta-analysis","volume":"22","author":"Ku","year":"2024","journal-title":"J Dtsch Dermatol Ges"},{"key":"2026062312163763000_ljag163-B3","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1038\/s41467-025-56719-8","article-title":"GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets","volume":"16","author":"Dand","year":"2025","journal-title":"Nat Comm"},{"key":"2026062312163763000_ljag163-B4","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/art.42154","article-title":"Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modeling","volume":"74","author":"Soomro","year":"2022","journal-title":"Arth Rheumatol"},{"key":"2026062312163763000_ljag163-B5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/exd.12081","article-title":"Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques","volume":"22","author":"Faurschou","year":"2013","journal-title":"Exp Dermatol"},{"key":"2026062312163763000_ljag163-B6","first-page":"100979","article-title":"GLP-1 based therapies and disease course of inflammatory bowel disease","volume":"37","author":"Villumsen","year":"2021","journal-title":"EClinMed"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag163\/68173591\/ljag163.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/1\/184\/68173591\/ljag163.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/1\/184\/68173591\/ljag163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:16:44Z","timestamp":1782231404000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/195\/1\/184\/8663832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,4,28]]},"published-print":{"date-parts":[[2026,6,23]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag163","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,4,28]]}}}