{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:44:03Z","timestamp":1792457043612,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573980"],"award-info":[{"award-number":["82573980"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972941"],"award-info":[{"award-number":["81972941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ70122"],"award-info":[{"award-number":["2026JJ70122"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ70127"],"award-info":[{"award-number":["2026JJ70127"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence regarding the role of haematopoietic mosaic loss of chromosome Y (mLOY) in the risk of incident dermatitis and eczema (DE), and its contribution to male susceptibility to DE, remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the associations of mLOY with incident DE and to assess whether mLOY may contribute to sex differences in DE susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 189 572 men enrolled in UK Biobank who were free of DE at baseline, recruited between 2006 and 2010. Haematopoietic mLOY was derived from genotyping intensity data and analysed as both categorical mLOY status and continuous mLOY percentage (mLOY%). Cox proportional hazards models were used to estimate associations with incident DE. Sex susceptibility was evaluated in a 1 : 1 propensity score-matched male\u2013female cohort. Genetic modification was assessed using a DE polygenic risk score (PRS), and mediation by circulating metabolites was explored via metabolomics analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, 9608 men developed DE. In fully adjusted models, both low mLOY (8\u201320%) and high mLOY (&amp;gt;20%) were associated with increased DE risk, with the strongest association found for high mLOY [adjusted hazard ratio (aHR) 1.44, 95% confidence interval (CI) 1.26\u20131.66; P \u00a0&amp;lt; 0.001]. Compared with women, men without detectable mLOY had a similar risk of DE, whereas men with low mLOY and high mLOY had progressively higher risks [aHR 1.14 (95% CI 1.07\u20131.21) and aHR 1.52 (95% CI 1.32\u20131.74), respectively], supporting a contribution of mLOY to male susceptibility to DE. In age\u2013mLOY discordance analyses, younger men with high mLOY showed a DE risk approaching that of older men without high mLOY, consistent with accelerated biologic ageing. The greatest risk was found in men with high mLOY and high PRS (aHR 1.85, 95% CI 1.49\u20132.31; P \u00a0&amp;lt; 0.001). In metabolomic analyses, 98 circulating metabolites significantly mediated the mLOY\u2013DE association, predominantly lipoprotein-related traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Haematopoietic mLOY was associated with an increased risk of incident DE and may contribute to late-life sex differences in DE susceptibility. Lipoprotein-centric mediation signals implicate modifiable metabolic pathways and support integrating mLOY status and lipid profiling into the risk assessment for older men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag219","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:45:50Z","timestamp":1779882350000},"page":"793-805","source":"Crossref","is-referenced-by-count":0,"title":["Association of haematopoietic mosaic loss of chromosome Y with dermatitis and eczema risk: an analysis in a large-scale prospective cohort study"],"prefix":"10.1093","volume":"195","author":[{"given":"Yajia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Institute of Geriatric Medicine, Hunan Provincial People\u2019s Hospital (The First-affiliated Hospital of Hunan Normal University) , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Trauma Surgery, Trauma Medicine Center, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Department of Emergency Medicine, Emergency Medicine and Difficult Disease Institute, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-278X","authenticated-orcid":false,"given":"Yunsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"2026101908585744200_ljag219-B1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/jid.2013.446","article-title":"The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions","volume":"134","author":"Hay","year":"2014","journal-title":"J Invest Dermatol"},{"key":"2026101908585744200_ljag219-B2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD","year":"2020","journal-title":"Lancet"},{"key":"2026101908585744200_ljag219-B3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.jid.2017.03.029","article-title":"Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK","volume":"137","author":"Abuabara","year":"2017","journal-title":"J Invest Dermatol"},{"key":"2026101908585744200_ljag219-B4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13223-023-00785-4","article-title":"Validation of a primary care electronic medical records case definition for eczema: retrospective cross-sectional study","volume":"19","author":"Stirton","year":"2023","journal-title":"Allergy Asthma Clin Immunol"},{"key":"2026101908585744200_ljag219-B5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258219","article-title":"The epidemiology of atopic dermatitis in older adults: a population-based study in the United Kingdom","volume":"16","author":"Chan","year":"2021","journal-title":"PLOS ONE"},{"key":"2026101908585744200_ljag219-B6","first-page":"1","article-title":"Frequency of atopic dermatitis and psoriasis in the elderly: cross-sectional findings from the German AugUR Study","volume":"241","author":"Drewitz","year":"2025","journal-title":"Dermatology"},{"key":"2026101908585744200_ljag219-B7","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/jcm14030840","article-title":"Temporal and topographical heterogeneities in clinical manifestations of atopic dermatitis in China","volume":"14","author":"Li","year":"2025","journal-title":"J Clin Med"},{"key":"2026101908585744200_ljag219-B8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.7326\/M18-2246","article-title":"Prevalence of atopic eczema among patients seen in primary care: data from The Health Improvement Network","volume":"170","author":"Abuabara","year":"2019","journal-title":"Ann Intern Med"},{"key":"2026101908585744200_ljag219-B9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/cea.13784","article-title":"The epidemiology of eczema in children and adults in England: a population-based study using primary care data","volume":"51","author":"de Lusignan","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"2026101908585744200_ljag219-B10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3345\/cep.2019.01291","article-title":"Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008\u20132017","volume":"63","author":"Ha","year":"2020","journal-title":"Clin Exp Pediatr"},{"key":"2026101908585744200_ljag219-B11","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v103.13363","article-title":"Atopic dermatitis in the elderly population","volume":"103","author":"Maurelli","year":"2023","journal-title":"Acta Derm Venereol"},{"key":"2026101908585744200_ljag219-B12","doi-asserted-by":"crossref","DOI":"10.2340\/actadv.v102.2287","article-title":"Age-dependent distribution of atopic dermatitis in primary care: a nationwide population-based study from Finland","volume":"102","author":"Salava","year":"2022","journal-title":"Acta Derm Venereol"},{"key":"2026101908585744200_ljag219-B13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-019-1765-3","article-title":"Genetic predisposition to mosaic Y chromosome loss in blood","volume":"575","author":"Thompson","year":"2019","journal-title":"Nature"},{"key":"2026101908585744200_ljag219-B14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ng.3821","article-title":"Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility","volume":"49","author":"Wright","year":"2017","journal-title":"Nat Genet"},{"key":"2026101908585744200_ljag219-B15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ajhg.2024.12.014","article-title":"Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood","volume":"112","author":"Jakubek","year":"2025","journal-title":"Am J Hum Genet"},{"key":"2026101908585744200_ljag219-B16","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00968-2024","article-title":"Mosaic loss of chromosome Y, tobacco smoking and risk of age-related lung diseases: insights from two prospective cohorts","volume":"64","author":"Weng","year":"2024","journal-title":"Eur Respir J"},{"key":"2026101908585744200_ljag219-B17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.abn3100","article-title":"Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality","volume":"377","author":"Sano","year":"2022","journal-title":"Science"},{"key":"2026101908585744200_ljag219-B18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ng.2966","article-title":"Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer","volume":"46","author":"Forsberg","year":"2014","journal-title":"Nat Genet"},{"key":"2026101908585744200_ljag219-B19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13578-023-01075-7","article-title":"Circulating macrophages as the mechanistic link between mosaic loss of Y-chromosome and cardiac disease","volume":"13","author":"Xu","year":"2023","journal-title":"Cell Biosci"},{"key":"2026101908585744200_ljag219-B20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"2026101908585744200_ljag219-B21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jaad.2024.05.106","article-title":"Clinical consequences of age-related skin barrier dysfunction: Part II. Approach to barrier dysfunction in the geriatric population","volume":"93","author":"Sanders","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"2026101908585744200_ljag219-B22","article-title":"Atopic dermatitis: pathogenesis and therapeutic intervention","volume":"5","author":"Yue","year":"(2020) 2024","journal-title":"MedComm"},{"key":"2026101908585744200_ljag219-B23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4428","article-title":"Prospective study design and data analysis in UK Biobank","volume":"16","author":"Allen","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026101908585744200_ljag219-B24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"2026101908585744200_ljag219-B25","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ng.3545","article-title":"Mosaic loss of chromosome Y is associated with common variation near TCL1A","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"2026101908585744200_ljag219-B26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/1871528110908050398","article-title":"Atopic dermatitis in the elderly","volume":"8","author":"Tanei","year":"2009","journal-title":"Inflamm Allergy Drug Targets"},{"key":"2026101908585744200_ljag219-B27","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41576-024-00805-y","article-title":"The effects of loss of Y chromosome on male health","volume":"26","author":"Bruhn-Olszewska","year":"2025","journal-title":"Nat Rev Genet"},{"key":"2026101908585744200_ljag219-B28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/s41586-025-09071-2","article-title":"Concurrent loss of the Y chromosome in cancer and T cells impacts outcome","volume":"642","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"2026101908585744200_ljag219-B29","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/eurheartj\/ehad093","article-title":"Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement","volume":"44","author":"Mas-Peiro","year":"2023","journal-title":"Eur Heart J"},{"key":"2026101908585744200_ljag219-B30","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/eurheartj\/ehaf035","article-title":"Mosaic loss of Y chromosome and mortality after coronary angiography","volume":"46","author":"Weyrich","year":"2025","journal-title":"Eur Heart J"},{"key":"2026101908585744200_ljag219-B31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s43856-025-00966-9","article-title":"Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis","volume":"5","author":"Bjurling","year":"2025","journal-title":"Commun Med (Lond)"},{"key":"2026101908585744200_ljag219-B32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tem.2016.11.002","article-title":"Context-dependent role of oxidized lipids and lipoproteins in inflammation","volume":"28","author":"Miller","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"2026101908585744200_ljag219-B33","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1824624","article-title":"The role of Toll-like receptors in skin host defense, psoriasis, and atopic dermatitis","volume":"2019","author":"Sun","year":"2019","journal-title":"J Immunol Res"},{"key":"2026101908585744200_ljag219-B34","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2026101908585744200_ljag219-B35","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adv4071","article-title":"Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease","volume":"17","author":"Arai","year":"2025","journal-title":"Sci Transl Med"},{"key":"2026101908585744200_ljag219-B36","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102294","article-title":"Lipids and lipid metabolism in cellular senescence: emerging targets for age-related diseases","volume":"97","author":"Zeng","year":"2024","journal-title":"Ageing Res Rev"},{"key":"2026101908585744200_ljag219-B37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jdermsci.2024.04.002","article-title":"Senescent fibroblasts and innate immune cell activation might play a role in the pathogenesis of elderly atopic dermatitis","volume":"114","author":"Luo","year":"2024","journal-title":"J Dermatol Sci"},{"key":"2026101908585744200_ljag219-B38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight"},{"key":"2026101908585744200_ljag219-B39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3390\/cells10051061","article-title":"HDL in immune-inflammatory responses: implications beyond cardiovascular diseases","volume":"10","author":"Bonacina","year":"2021","journal-title":"Cells"},{"key":"2026101908585744200_ljag219-B40","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1387128","article-title":"Effects of Th1\/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes","volume":"16","author":"Cavallo","year":"2025","journal-title":"Front Physiol"},{"key":"2026101908585744200_ljag219-B41","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12964-024-01624-8","article-title":"Emerging roles of lactate in acute and chronic inflammation","volume":"22","author":"Fang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"2026101908585744200_ljag219-B42","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41419-019-1877-6","article-title":"Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling","volume":"10","author":"Tauffenberger","year":"2019","journal-title":"Cell Death Dis"},{"key":"2026101908585744200_ljag219-B43","article-title":"Dietary D-lactate intake facilitates inflammatory resolution by modulating M1 macrophage polarization","volume":"66","author":"Yan","year":"2022","journal-title":"Mol Nutr Food Res"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag219\/68413125\/ljag219.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/5\/793\/68413125\/ljag219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/5\/793\/68413125\/ljag219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:59:08Z","timestamp":1792414748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/195\/5\/793\/8696356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,28]]},"published-print":{"date-parts":[[2026,10,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag219","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,5,28]]}}}