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Although disease worsening was observed in several patients initially diagnosed with presumed inflammatory dermatoses, causality cannot necessarily be inferred and may reflect, among other factors, underlying MF\/SS biology, referral bias or concurrent immunosuppressive influences. In patients with post-transplant MF\/SS receiving JAKi for graft-versus-host disease, MF\/SS progression may reflect impaired immune surveillance or other disease-related factors rather than a direct effect of JAKi. These findings underscore the complexity of interpreting JAKi exposure in MF\/SS and highlight the need for prospective studies to better define risks across clinical settings.<\/jats:p>","DOI":"10.1093\/bjd\/ljag240","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:31:43Z","timestamp":1781335903000},"page":"550-551","source":"Crossref","is-referenced-by-count":0,"title":["Comment on \u2018Context, not class, may be the key signal in systemic Janus kinase inhibitor exposure in mycosis fungoides\/S\u00e9zary syndrome\u2019: reply from authors"],"prefix":"10.1093","volume":"195","author":[{"given":"Iris","family":"Amitay-Laish","sequence":"first","affiliation":[{"name":"Division of Dermatology, Rabin Medical Center \u2013 Beilinson Hospital, and Gray Faculty of Medical and Health Sciences, Tel-Aviv University , Tel Aviv 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