{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:42:34Z","timestamp":1792417354613,"version":"4.4.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130089"],"award-info":[{"award-number":["82130089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271864"],"award-info":[{"award-number":["82271864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371746"],"award-info":[{"award-number":["82371746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504260"],"award-info":[{"award-number":["82504260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Keloids represent a prevalent form of pathological scarring, yet their treatment remains highly challenging in clinical practice. The pathogenesis of keloids remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the function and mechanism of amphiregulin (AREG) in keloids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed transcriptomic profiling of keloid fibroblasts (KFs) and normal fibroblasts (NFs). Keloid skin explants and keloid-bearing nude mice were used to explore the roles of AREG in keloids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AREG was upregulated in keloids and associated with disease severity. In vitro recombinant AREG promoted proliferation, migration and extracellular matrix (ECM) production in KFs. We further demonstrated that AREG signalling mediates keloid fibroblast activation through the epidermal growth factor receptor (EGFR). In addition, we revealed that the MAPK signalling pathway functions as a key downstream effector of the AREG-EGFR axis. As an EGFR antagonist, gefitinib effectively reduced ECM component deposition in both keloid skin explants and a nude mouse xenograft model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results not only highlight the role of AREG in driving keloid progression but also point to the translational relevance of gefitinib as a viable therapeutic candidate for keloids.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag289","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:49:43Z","timestamp":1784116183000},"page":"818-829","source":"Crossref","is-referenced-by-count":2,"title":["The amphiregulin\u2013epidermal growth factor receptor axis\u00a0drives fibroblast activation to promote keloid progression"],"prefix":"10.1093","volume":"195","author":[{"given":"Enzhu","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqi","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huinan","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zican","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-6649","authenticated-orcid":false,"given":"Juan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) , Wuhan ,","place":["China"]},{"name":"Hubei Engineering Research Centre for Skin Repair and Theranostics , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026101908574693900_ljag289-B1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1001\/jamadermatol.2020.4705","article-title":"Glass DA 2nd","volume":"157","author":"Jagdeo","year":"2021","journal-title":"Keloids. JAMA Dermatol"},{"key":"2026101908574693900_ljag289-B2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"Jeschke","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"2026101908574693900_ljag289-B3","doi-asserted-by":"crossref","first-page":"a041245","DOI":"10.1101\/cshperspect.a041245","article-title":"Keloid disorder: genetic basis, gene expression profiles, and immunological modulation of the fibrotic processes in the skin","volume":"15","author":"Cohen","year":"2023","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026101908574693900_ljag289-B4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.annder.2022.08.010","article-title":"Keloid disease: review with clinical atlas. Part I: definitions, history, epidemiology, clinics and diagnosis","volume":"150","author":"Delaleu","year":"2023","journal-title":"Ann Dermatol Venereol"},{"key":"2026101908574693900_ljag289-B5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamadermatol.2022.5607","article-title":"Comorbidities of keloid and hypertrophic scars among participants in UK Biobank","volume":"159","author":"Ung","year":"2023","journal-title":"JAMA Dermatol"},{"key":"2026101908574693900_ljag289-B6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/ijd.15159","article-title":"Keloids: a review of therapeutic management","volume":"60","author":"Ekstein","year":"2021","journal-title":"Int J Dermatol"},{"key":"2026101908574693900_ljag289-B7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/iwj.13104","article-title":"Managing keloid scars: from radiation therapy to actual and potential drug deliveries","volume":"16","author":"Huang","year":"2019","journal-title":"Int Wound J"},{"key":"2026101908574693900_ljag289-B8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40257-022-00744-6","article-title":"Hypertrophic scars and keloids: advances in treatment and review of established therapies","volume":"24","author":"Frech","year":"2023","journal-title":"Am J Clin Dermatol"},{"key":"2026101908574693900_ljag289-B9","doi-asserted-by":"crossref","first-page":"906212","DOI":"10.3389\/fphar.2022.906212","article-title":"Biomechanical regulatory factors and therapeutic targets in keloid fibrosis","volume":"13","author":"Feng","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026101908574693900_ljag289-B10","doi-asserted-by":"crossref","first-page":"eadn7871","DOI":"10.1126\/scitranslmed.adn7871","article-title":"Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis","volume":"16","author":"Li","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026101908574693900_ljag289-B11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2018.08.009","article-title":"Current and upcoming therapies to modulate skin scarring and fibrosis","volume":"146","author":"Coentro","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"2026101908574693900_ljag289-B12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/exd.14243","article-title":"Keloid disorder: fibroblast differentiation and gene expression profile in fibrotic skin diseases","volume":"30","author":"Macarak","year":"2021","journal-title":"Exp Dermatol"},{"key":"2026101908574693900_ljag289-B13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12964-023-01214-0","article-title":"Characterization of the skin keloid microenvironment","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun Signal"},{"key":"2026101908574693900_ljag289-B14","doi-asserted-by":"crossref","first-page":"1117630","DOI":"10.3389\/fimmu.2023.1117630","article-title":"An updated review of the immunological mechanisms of keloid scars","volume":"14","author":"Lee","year":"2023","journal-title":"Front Immunol"},{"key":"2026101908574693900_ljag289-B15","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"2026101908574693900_ljag289-B16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.12688\/f1000research.8190.1","article-title":"The myofibroblast in wound healing and fibrosis: answered and unanswered questions","volume":"5","author":"Bochaton-Piallat","year":"2016","journal-title":"F1000Res"},{"key":"2026101908574693900_ljag289-B17","doi-asserted-by":"crossref","first-page":"dmm044164","DOI":"10.1242\/dmm.044164","article-title":"Understanding the impact of fibroblast heterogeneity on skin fibrosis","volume":"13","author":"Griffin","year":"2020","journal-title":"Dis Model Mech"},{"key":"2026101908574693900_ljag289-B18","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","article-title":"Recent developments in myofibroblast biology: paradigms for connective tissue remodeling","volume":"180","author":"Hinz","year":"2012","journal-title":"Am J Pathol"},{"key":"2026101908574693900_ljag289-B19","doi-asserted-by":"crossref","first-page":"111074","DOI":"10.1016\/j.celrep.2022.111074","article-title":"Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming","volume":"40","author":"von Joest","year":"2022","journal-title":"Cell Rep"},{"key":"2026101908574693900_ljag289-B20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.immuni.2015.01.020","article-title":"Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair","volume":"42","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"2026101908574693900_ljag289-B21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/antiox13010078","article-title":"Amphiregulin exerts proangiogenic effects in developing murine lungs","volume":"13","author":"Thapa","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"2026101908574693900_ljag289-B22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"2026101908574693900_ljag289-B23","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.immuni.2021.04.002","article-title":"Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections","volume":"54","author":"Harb","year":"2021","journal-title":"Immunity"},{"key":"2026101908574693900_ljag289-B24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jaci.2023.11.916","article-title":"Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease","volume":"153","author":"Koga","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"2026101908574693900_ljag289-B25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/ajt.15743","article-title":"Amphiregulin as a driver of tissue fibrosis","volume":"20","author":"Zaiss","year":"2020","journal-title":"Am J Transplant"},{"key":"2026101908574693900_ljag289-B26","doi-asserted-by":"crossref","first-page":"e173593","DOI":"10.1172\/JCI173593","article-title":"Dysregulated Treg repair responses lead to chronic rejection after heart transplantation","volume":"134","author":"Warunek","year":"2024","journal-title":"J Clin Invest"},{"key":"2026101908574693900_ljag289-B27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.immuni.2024.01.009","article-title":"Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis","volume":"57","author":"Savage","year":"2024","journal-title":"Immunity"},{"key":"2026101908574693900_ljag289-B28","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/stmcls\/sxae035","article-title":"Amphiregulin secreted by umbilical cord multipotent stromal cells protects against ferroptosis of macrophages via the activating transcription factor 3-CD36 axis to alleviate endometrial fibrosis","volume":"42","author":"Wang","year":"2024","journal-title":"Stem Cells"},{"key":"2026101908574693900_ljag289-B29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ptr.7599","article-title":"Quercetin inhibits the amphiregulin\/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy","volume":"37","author":"Wang","year":"2023","journal-title":"Phytother Res"},{"key":"2026101908574693900_ljag289-B30","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/cells11060986","article-title":"EGFR signaling in lung fibrosis","volume":"11","author":"Schramm","year":"2022","journal-title":"Cells"},{"key":"2026101908574693900_ljag289-B31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.immuni.2018.04.023","article-title":"Amphiregulin-producing pathogenic memory T helper 2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis","volume":"49","author":"Morimoto","year":"2018","journal-title":"Immunity"},{"key":"2026101908574693900_ljag289-B32","doi-asserted-by":"crossref","first-page":"105138","DOI":"10.1016\/j.ebiom.2024.105138","article-title":"Mucosal-associated invariant T cells promote ductular reaction through amphiregulin in biliary atresia","volume":"103","author":"Xiao","year":"2024","journal-title":"EBioMedicine"},{"key":"2026101908574693900_ljag289-B33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/j.gastro.2022.09.006","article-title":"Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts","volume":"164","author":"Zhao","year":"2023","journal-title":"Gastroenterology"},{"key":"2026101908574693900_ljag289-B34","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.stem.2024.07.004","article-title":"Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis","volume":"31","author":"Zhao","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2026101908574693900_ljag289-B35","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1038\/s41467-022-30633-9","article-title":"Identification, discrimination and heterogeneity of fibroblasts","volume":"13","author":"Lendahl","year":"2022","journal-title":"Nat Commun"},{"key":"2026101908574693900_ljag289-B36","doi-asserted-by":"crossref","first-page":"21192","DOI":"10.1038\/s41598-020-78292-4","article-title":"Human skin explant model for the investigation of topical therapeutics","volume":"10","author":"Neil","year":"2020","journal-title":"Sci Rep"},{"key":"2026101908574693900_ljag289-B37","first-page":"69","article-title":"The use of skin models in drug development","author":"Mathes","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"2026101908574693900_ljag289-B38","doi-asserted-by":"crossref","first-page":"e70015","DOI":"10.1111\/wrr.70015","article-title":"Comprehensive analysis of keloid vasculature by tissue clearing and 3D imaging","volume":"33","author":"Nguyen","year":"2025","journal-title":"Wound Repair Regen"},{"key":"2026101908574693900_ljag289-B39","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3389\/fimmu.2019.01810","article-title":"Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies","volume":"10","author":"Tan","year":"2019","journal-title":"Front Immunol"},{"key":"2026101908574693900_ljag289-B40","doi-asserted-by":"crossref","first-page":"117129","DOI":"10.1016\/j.celrep.2026.117129","article-title":"Natural killer cell dysfunction drives keloid pathogenesis","volume":"45","author":"Zhao","year":"2026","journal-title":"Cell Rep"},{"key":"2026101908574693900_ljag289-B41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.matbio.2016.01.013","article-title":"Keloids: the paradigm of skin fibrosis \u2013 pathomechanisms and treatment","volume":"51","author":"Andrews","year":"2016","journal-title":"Matrix Biol"},{"key":"2026101908574693900_ljag289-B42","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.immuni.2019.01.008","article-title":"A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation","volume":"50","author":"Minutti","year":"2019","journal-title":"Immunity"},{"key":"2026101908574693900_ljag289-B43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s12931-022-02285-2","article-title":"Amphiregulin induces CCN2 and fibronectin expression by TGF-\u03b2 through EGFR-dependent pathway in lung epithelial cells","volume":"23","author":"Cheng","year":"2022","journal-title":"Respir Res"},{"key":"2026101908574693900_ljag289-B44","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nrc1506","article-title":"Gefitinib \u2013 a novel targeted approach to treating cancer","volume":"4","author":"Herbst","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"2026101908574693900_ljag289-B45","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/annonc\/mdp387","article-title":"Gefitinib for advanced non-small-cell lung cancer and quality of life: expanding and improving treatment options","volume":"20","author":"William","year":"2009","journal-title":"Ann Oncol"},{"key":"2026101908574693900_ljag289-B46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.20538","article-title":"Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis","volume":"41","author":"Schiffer","year":"2005","journal-title":"Hepatology"},{"key":"2026101908574693900_ljag289-B47","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1681\/ASN.2011050493","article-title":"Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis","volume":"23","author":"Liu","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2026101908574693900_ljag289-B48","doi-asserted-by":"crossref","first-page":"120283","DOI":"10.1016\/j.lfs.2021.120283","article-title":"Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis","volume":"291","author":"Velagacherla","year":"2022","journal-title":"Life Sci"},{"key":"2026101908574693900_ljag289-B49","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1038\/s41467-021-27612-x","article-title":"Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling","volume":"12","author":"Zindel","year":"2021","journal-title":"Nat Commun"},{"key":"2026101908574693900_ljag289-B50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41392-022-00959-3","article-title":"Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026101908574693900_ljag289-B51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1470-2045(09)70364-X","article-title":"Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomized phase 3 trial","volume":"11","author":"Mitsudomi","year":"2010","journal-title":"Lancet Oncol"},{"key":"2026101908574693900_ljag289-B52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s40264-013-0048-4","article-title":"Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives","volume":"36","author":"Shah","year":"2013","journal-title":"Drug Saf"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag289\/69834377\/ljag289.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/5\/818\/69834377\/ljag289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/article-pdf\/195\/5\/818\/69834377\/ljag289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:58:07Z","timestamp":1792414687000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/article\/195\/5\/818\/8740169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,7,23]]},"published-print":{"date-parts":[[2026,10,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag289","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,7,23]]}}}