{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:23:21Z","timestamp":1787747001393,"version":"build-2784847793"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few validated diagnostic criteria for atopic dermatitis (AD) can diagnose AD without a clinician\u2019s exam, and even fewer are validated in very young children. Recently, the Community-based Assessment of Skin Care, Allergies, and Eczema (CASCADE) prevention trial remotely captured parent\/caregiver responses to the Childhood Eczema Questionnaire and a Proxy Report of a Clinician AD Diagnosis in children \u22642 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the performance of Childhood Eczema Questionnaire and Proxy Report of a Clinician AD Diagnosis for the purpose of remote AD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from the CASCADE trial was used to calculate the sensitivity, specificity, positive predictive value, and negative predictive value of Childhood Eczema Questionnaire or Proxy Report of a Clinician AD Diagnosis at 12 and 24 months of age in 933 participants with data available for comparison against the reference standard of a clinician\u2019s chart diagnosis of AD, present in 26.2% (244\/933 at 24 months) of the cohort. Clinicians who acted as the reference standard were primary care clinicians or pediatricians who received additional training in diagnosing AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Proxy Report of a Clinician AD Diagnosis displayed sensitivity\/specificity at 12 months (65.8%\/91.3%) and 71.6%\/93.2% at 24 months. It also displayed positive and negative predictive values of 72.5%\/88.5% at 12 months and 88.3%\/82.2% 24 months. The Childhood Eczema Questionnaire showed sensitivity, specificity, positive and negative predictive values of 46.3%\/91.5%\/64.5%\/83.5% at 12 months and 50.9%\/93.2%\/84.1%\/72.8% at 24 months. A lack of proxy-observed or reported itch or rash were the most common reasons for Childhood Eczema Questionnaire false negative cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Proxy Report of a Clinician AD Diagnosis performed well for sensitivity, specificity, positive and negative predictive values, followed by Childhood Eczema Questionnaire. This U.S. study provides new evidence that supports Proxy Report of a Clinician AD Diagnosis as an adequate approach to identify eczema cases remotely for research in children &amp;lt;2 with access to healthcare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag347","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:35:45Z","timestamp":1787657745000},"source":"Crossref","is-referenced-by-count":0,"title":["Remote identification of new onset pediatric atopic dermatitis - a comparison of diagnostic methods from a post-hoc analysis of the CASCADE prevention trial"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9419-4704","authenticated-orcid":false,"given":"Milie M","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-5626","authenticated-orcid":false,"given":"Jordan","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8770-328X","authenticated-orcid":false,"given":"Robyn","family":"Okereke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-0456","authenticated-orcid":false,"given":"Cynthia D","family":"Morris","sequence":"additional","affiliation":[{"name":"Oregon Clinical and Translational Research Institute, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-3093","authenticated-orcid":false,"given":"Hywel C","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre of Evidence-based Dermatology, Lifespan and Population Health, University of Nottingham , Nottingham, England ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8258-9412","authenticated-orcid":false,"given":"Mary F","family":"Henningfield","sequence":"additional","affiliation":[{"name":"Wisconsin Research and Education Network, University of Wisconsin-Madison , Madison, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-3720","authenticated-orcid":false,"given":"Donald E","family":"Nease","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Colorado-Anschutz Medical Campus , Aurora, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-9468","authenticated-orcid":false,"given":"Rowena J","family":"Dolor","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-0087","authenticated-orcid":false,"given":"Katrina","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Biostatistics and Design Program, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-0061","authenticated-orcid":false,"given":"Annette","family":"Vu","sequence":"additional","affiliation":[{"name":"Oregon Clinical and Translational Research Institute, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4073-9293","authenticated-orcid":false,"given":"LeAnn C","family":"Michaels","sequence":"additional","affiliation":[{"name":"Division of Informatics, Clinical Epidemiology and Translational Data Science, Department of Medicine, Oregon Health & Science University , Portland, OR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-0252","authenticated-orcid":false,"given":"Eric L","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Oregon Health & Science University , Portland, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag347\/70793265\/ljag347.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag347\/70793265\/ljag347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:01:37Z","timestamp":1787745697000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article\/doi\/10.1093\/bjd\/ljag347\/8770943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag347","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"ljag347"}}