{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:50:10Z","timestamp":1792047010878,"version":"4.4.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M763893"],"award-info":[{"award-number":["2024M763893"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Youth Foundation of Chongqing Province","award":["CSTB2024YCJH-KYXM0101"],"award-info":[{"award-number":["CSTB2024YCJH-KYXM0101"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573959"],"award-info":[{"award-number":["82573959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82606777"],"award-info":[{"award-number":["82606777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Previous studies of metabolic dysregulation in psoriatic disease (PsD) have largely focused on single metabolic factors. Comprehensive scores, such as MetaboHealth and the Metabolic Vulnerability Index (MVX), have not been systematically explored in PsD. In this prospective cohort study using UK Biobank data, we showed that MetaboHealth and MVX were associated with PsD risk independent of confounders, particularly in individuals with a high genetic predisposition.<\/jats:p>","DOI":"10.1093\/bjd\/ljag433","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:57:18Z","timestamp":1790769438000},"source":"Crossref","is-referenced-by-count":0,"title":["MetaboHealth, Metabolic Vulnerability Index, genetic susceptibility and the risk of psoriatic disease"],"prefix":"10.1093","author":[{"given":"Xinyi","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4231-4454","authenticated-orcid":false,"given":"Zhaofu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingqiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Medical Aesthetics, Women and Children\u2019s Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital , Fuzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghe","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-9504","authenticated-orcid":false,"given":"Genlong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-209X","authenticated-orcid":false,"given":"Jingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101502410870500_ljag433-B1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/annrheumdis-2011-200567","article-title":"Cardiovascular and metabolic risks in psoriasis and psoriatic arthritis: pragmatic clinical management based on available evidence","volume":"71","author":"Johnsson","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2026101502410870500_ljag433-B2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1111\/jdv.19192","article-title":"Depression, a major comorbidity of psoriatic disease, is caused by metabolic inflammation","volume":"37","author":"Mrowietz","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026101502410870500_ljag433-B3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/bjd\/ljae268","article-title":"Life\u2019s Essential 8, genetic susceptibility and the risk of psoriatic disease: a prospective cohort study","volume":"191","author":"Ouyang","year":"2024","journal-title":"Br J Dermatol"},{"key":"2026101502410870500_ljag433-B4","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/S2666-7568(23)00001-6","article-title":"Multimarkers of metabolic malnutrition and inflammation and their association with mortality risk in cardiac catheterisation patients: a prospective, longitudinal, observational, cohort study","volume":"4","author":"Otvos","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"2026101502410870500_ljag433-B5","doi-asserted-by":"crossref","first-page":"9029","DOI":"10.1111\/dom.71112","article-title":"MetaboHealth and Metabolic Vulnerability Index as risk factors for cardio\u2013renal\u2013metabolic multimorbidity: a large-scale prospective cohort study","volume":"28","author":"Ke","year":"2026","journal-title":"Diabetes Obes Metab"},{"key":"2026101502410870500_ljag433-B6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/bjd\/ljaf463","article-title":"Sleep patterns and the risk of psoriatic disease: genetic predisposition and metabonomics","volume":"194","author":"Guo","year":"2026","journal-title":"Br J Dermatol"},{"key":"2026101502410870500_ljag433-B7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2017.01.009","article-title":"High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation","volume":"104","author":"Zhenyukh","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2026101502410870500_ljag433-B8","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1111\/jcmm.13759","article-title":"Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation","volume":"22","author":"Zhenyukh","year":"2018","journal-title":"J Cell Mol Med"}],"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag433\/71544804\/ljag433.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag433\/71544804\/ljag433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:41:14Z","timestamp":1792046474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article\/doi\/10.1093\/bjd\/ljag433\/8857150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":8,"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag433","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"ljag433"}}