{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:48:23Z","timestamp":1792043303543,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This letter comments on the recent real-world study by Marzano et al. evaluating topical ruxolitinib in non-segmental vitiligo. We raise a methodological concern regarding the interpretation of the seasonal treatment initiation effect, arguing that the superior early response observed in summer initiators may largely reflect unmeasured ambient UV exposure rather than a true drug\u2013UV synergy. We propose that target trial emulation using propensity score matching could reduce confounding and yield more robust estimates in future analyses.<\/jats:p>","DOI":"10.1093\/bjd\/ljag460","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:54:08Z","timestamp":1791978848000},"source":"Crossref","is-referenced-by-count":0,"title":["Summer Initiation of Ruxolitinib in Vitiligo: Natural Phototherapy Confounds the Seasonal Signal"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6103-4277","authenticated-orcid":false,"given":"Xiangyun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, The Seventh Affiliated Hospital of Sun Yat-sen University , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-6603","authenticated-orcid":false,"given":"Gang","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, The Seventh Affiliated Hospital of Sun Yat-sen University , Shenzhen, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,15]]},"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag460\/71954333\/ljag460.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag460\/71954333\/ljag460.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:23:12Z","timestamp":1792041792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article\/doi\/10.1093\/bjd\/ljag460\/8916720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag460","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"article-number":"ljag460"}}