{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:47:08Z","timestamp":1792583228766,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS)-specific quality of life (QOL) is one of six core domains for HS studies defined by HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC). The 17-item Hidradenitis Suppurativa Quality of Life (HiSQOL\u00a9) questionnaire was developed and validated by HISTORIC to measure this domain. A shortened version would be easier for routine clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To produce a shortened version of HiSQOL by selecting a subset of the original 17 items.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Item selection for HiSQOL-mini was informed by correlation analyses on two datasets from the Treatment of Hidradenitis Suppurativa Evaluation Study (THESEUS) and the BE HEARD I and II Phase 3 trials. Spearman\u2019s rank correlation coefficients were calculated between each item and the HiSQOL total score after omitting that item. Two consensus workshops were then conducted, with patient research partners (PRPs) leading the discussions, to finalise the items for inclusion. Analyses to assess psychometric performance and derive interpretation thresholds for HiSQOL-mini were conducted using the BE HEARD dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the symptoms sub-domain, pain exhibited the highest correlation with HiSQOL total score and was unanimously selected at the end of Workshop 1. In the psychosocial sub-domain, the \u2018down or depressed\u2019 item performed best from THESEUS data, while the \u2018concentration\u2019 and \u2018embarrassed\u2019 items performed best from BE HEARD data. Related to content validity, PRPs prioritised \u2018down or depressed\u2019 in the discussions. \u2018Walking\u2019 performed well in both datasets and PRPs further recommended inclusion of a second activities-adaptations item, \u2018getting dressed\u2019. HiSQOL-mini demonstrated good validity, reliability and responsiveness, and has scores ranging from 0\u201316. Minimal important difference was a 3-point reduction and clinically meaningful change was a 5-point reduction. Severity thresholds for HiSQOL-mini score were 0 for \u2018none\u2019, 1\u20132 for \u2018mild\u2019, 3\u20134 for \u2018moderate\u2019, 5\u20136 for \u2018severe\u2019 and 7\u201316 for \u2018very severe\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HiSQOL-mini, using the same item format as HiSQOL, contains four items relating to \u2018pain\u2019, feeling \u2018down or depressed\u2019, \u2018walking\u2019 and \u2018getting dressed\u2019. HiSQOL-mini is a valid, reliable and responsive questionnaire to measure health-related QOL in patients with HS and should be swift to perform.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjd\/ljag468","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:33:16Z","timestamp":1792582396000},"source":"Crossref","is-referenced-by-count":0,"title":["HiSQOL-mini: Development and Validation of a Shortened Version of the Hidradenitis Suppurativa Quality of Life (HiSQOL) Instrument"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-1142","authenticated-orcid":false,"given":"John R","family":"Ingram","sequence":"first","affiliation":[{"name":"Division of Infection & Immunity, Cardiff University , Cardiff ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Espy","sequence":"additional","affiliation":[{"name":"The Association of Hidradenitis Suppurativa and Inflammatory Diseases , Detroit, Michigan ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-6856","authenticated-orcid":false,"given":"Amit","family":"Garg","sequence":"additional","affiliation":[{"name":"Northwell Health , New Hyde Park, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Patient Advocate and Research Partner ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Gierbolini","sequence":"additional","affiliation":[{"name":"Patient Representative , Mount Joy, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Hasan","sequence":"additional","affiliation":[{"name":"Division of Infection & Immunity, Cardiff University , Cardiff ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2540","authenticated-orcid":false,"given":"Gregor B","family":"Jemec","sequence":"additional","affiliation":[{"name":"PHOENIX Research Centre, Department of Dermatology, Herlev-Gentofte Hospital , Hellerup ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joslyn","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Penn State University , Hershey, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry M","family":"McGrath","sequence":"additional","affiliation":[{"name":"HS Ireland, Hidradenitis Suppurativa Association , County Clare ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7743-0234","authenticated-orcid":false,"given":"Tim","family":"Pickles","sequence":"additional","affiliation":[{"name":"School of Humanities and Social Sciences, Leeds Beckett University , Leeds ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Western Ontario, Windsor Clinical Research Inc ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-9607","authenticated-orcid":false,"given":"Linnea","family":"Thorlacius","sequence":"additional","affiliation":[{"name":"PHOENIX Research Centre, Department of Dermatology, Herlev-Gentofte Hospital , Hellerup ,","place":["Denmark"]},{"name":"Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Lambert","sequence":"additional","affiliation":[{"name":"UCB , Courbevoie ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys","family":"Warham","sequence":"additional","affiliation":[{"name":"Veramed , London ,","place":["UK"]},{"name":"UCB , Slough ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5176-2166","authenticated-orcid":false,"given":"Bente","family":"Villumsen","sequence":"additional","affiliation":[{"name":"Danish HS Patients\u2019 Association , Soborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"container-title":["British Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag468\/72239668\/ljag468.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article-pdf\/doi\/10.1093\/bjd\/ljag468\/72239668\/ljag468.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:33:16Z","timestamp":1792582396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjd\/advance-article\/doi\/10.1093\/bjd\/ljag468\/8963514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/bjd\/ljag468","relation":{},"ISSN":["0007-0963","1365-2133"],"issn-type":[{"value":"0007-0963","type":"print"},{"value":"1365-2133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"ljag468"}}