{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T08:01:51Z","timestamp":1783238511535,"version":"3.54.6"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1154","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare treatment volumes reconstructed from hybrid Angio-CT catheter-directed infusion imaging and Couinaud anatomic model as well as the implied differences in Y-90 radiation dosimetry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients who underwent transarterial radioembolization (TARE) using Y-90 glass microspheres with pretreatment CT or MRI imaging as well as intraprocedural angiography-CT (Angio-CT) were analysed. Treatment volumes were delineated using both tumoural angiosomes (derived from Angio-CT) and Couinaud anatomic landmarks. Segmental and lobar treatment volumes were calculated via semi-automated contouring software. Volume and dose differences were compared by the two-tailed Student t test or Wilcoxon signed-rank test. Factors affecting volume and dose differences were assessed via simple and\/or multiple variable linear regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From September 2018 to March 2021, 44 patients underwent 45 lobar treatments and 38 patients received 56 segmental treatments. All target liver lobes and all tumours were completely included within the field-of-view by Angio-CT. Tumour sizes ranged between 1.1 and 19.5 cm in diameter. Segmental volumes and treatment doses were significantly different between the Couinaud and Angio-CT volumetry methods (316 vs 404\u2009mL, P\u2009&amp;lt;\u2009.0001 and 253 vs 212\u2009Gy, P\u2009&amp;lt;\u2009.01, respectively). Watershed tumours were significantly correlated with underestimated volumes by the Couinaud anatomic model (P\u2009&amp;lt;\u2009.001). There was a significant linear relationship between tumour diameter and percent volume difference (R2 = 0.44, P\u2009&amp;lt;\u2009.0001). The Couinaud model overestimated volumes for large tumours that exhibited central hypovascularity\/necrosis and for superselected peripheral tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Angio-CT may confer advantages over the Couinaud anatomic model and enable more accurate, personalized dosimetry for TARE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>Angio-CT may confer advantages over traditional cross-sectional and cone-beam CT imaging for selective internal radiation therapy planning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqad056","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:09:31Z","timestamp":1704391771000},"page":"353-362","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative differences in volumetric calculations for radiation dosimetry in segmental Y90 treatment planning using hybrid angiography-CT compared with anatomic segmentation"],"prefix":"10.1093","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-0542","authenticated-orcid":false,"given":"Daniel H","family":"Kwak","sequence":"first","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Lionberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Nijhawan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cao","sequence":"additional","affiliation":[{"name":"The University of Chicago Pritzker School of Medicine , Chicago, IL 60637, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Youssef","sequence":"additional","affiliation":[{"name":"University College Dublin School of Medicine , Dublin 4, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Interventional Radiology, The University of Chicago Medical Center , Chicago, IL 60637, United 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