{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:31:16Z","timestamp":1774935076384,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1156","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008719","name":"Movember Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008719","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manchester\/Belfast Movember Centre of Excellence","award":["CE013_2-004"],"award-info":[{"award-number":["CE013_2-004"]}]},{"DOI":"10.13039\/100015663","name":"Friends of The Cancer Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to generate an objective method to describe MRI data to assess response in the vertebrae of patients with metastatic hormone sensitive prostate cancer (mHSPC), treated with external beam radiation therapy and systemic therapy with Radium-223 and to correlate changes with clinical outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Three sets of whole-body MRI (WBMRI) images were utilized from 25 patients from the neo-adjuvant Androgen Deprivation Therapy pelvic Radiotherapy and RADium-223 (ADRRAD) clinical trial: MRI1 (up to 28\u2009days before Radium-223), MRI2, and MRI3 (2 and 6\u2009months post completion of Radium-223). Radiological response was assessed based on post baseline MRI images. Vertebrae were semi-automatically contoured in the sagittal T1-weighted (T1w) acquisitions, MRI intensity was measured, and spinal cord was used to normalize the measurements. The relationship between MRI intensity vs time to biochemical progression and radiology response was investigated. Survival curves were generated and splitting measures for survival and biochemical progression investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using a splitting measure of 1.8, MRI1 was found to be a reliable quantitative indicator correlating with overall survival (P\u2009=\u20090.023) and biochemical progression (P\u2009=\u20090.014). MRI (3-1) and MRI (3-2) were found to be significant indicators for patients characterized by progressive\/non-progressive disease (P\u2009=\u20090.021, P\u2009=\u20090.004) and biochemical progression within\/after 12\u2009months (P\u2009=\u20090.007, P\u2009=\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We have identified a potentially useful objective measure of response on WBMRI of vertebrae containing bone metastases in mHSPC which correlates with survival\/progression (prognostic) and radiology response (predictive).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>Measurements of T1w WBMRI normalized intensity may allow identifying potentially useful response biomarkers correlating with survival, radiological response and biochemical progression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqae005","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T08:40:51Z","timestamp":1706172051000},"page":"794-802","source":"Crossref","is-referenced-by-count":1,"title":["An objective measure of response on whole-body MRI in metastatic hormone sensitive prostate cancer treated with androgen deprivation therapy, external beam radiotherapy, and radium-223"],"prefix":"10.1093","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-8242","authenticated-orcid":false,"given":"Valentina","family":"Giacometti","sequence":"first","affiliation":[{"name":"Advanced Radiotherapy Group, Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast , Belfast, Belfast, BT97 1NN, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur C","family":"Grey","sequence":"additional","affiliation":[{"name":"Department of Imaging Services, Belfast Health & Social Care Trust , Belfast, BT9 7AB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Radiological Imaging & Protection Service, Regional Medical Physics Service, Belfast Health & Social Care Trust , Belfast, BT9 7AB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M","family":"Prise","sequence":"additional","affiliation":[{"name":"Advanced Radiotherapy Group, Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast , Belfast, Belfast, BT97 1NN, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R","family":"Hounsell","sequence":"additional","affiliation":[{"name":"Advanced Radiotherapy Group, Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast , Belfast, Belfast, BT97 1NN, United Kingdom"},{"name":"Department of Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust , Belfast, BT9 7AB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor K","family":"McGarry","sequence":"additional","affiliation":[{"name":"Advanced Radiotherapy Group, Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast , Belfast, Belfast, BT97 1NN, United Kingdom"},{"name":"Department of Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust , Belfast, BT9 7AB, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G","family":"Turner","sequence":"additional","affiliation":[{"name":"St Luke\u2019s Cancer Centre, The Royal Hospital , Egerton Rd, Guildford GU2 7XX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe M","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Advanced Radiotherapy Group, Patrick G. 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