{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:07:38Z","timestamp":1787314058528,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1157","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Grant-in-Aid for Research in Nagoya City University","award":["2213003"],"award-info":[{"award-number":["2213003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of daily fraction doses on late genitourinary (GU) toxicity after salvage radiotherapy (SRT) for prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi-institutional retrospective study included 212 patients who underwent SRT between 2008 and 2018. All patients received image-guided intensity-modulated SRT at a median dose of 67.2\u2009Gy in 1.8-2.3\u2009Gy\/fraction. The cumulative rates of late grade \u22652 GU and gastrointestinal (GI) toxicities were compared using Gray test, stratified by the \u22642.0\u2009Gy\/fraction (n\u2009=\u2009137) and \u22652.1\u2009Gy\/fraction groups (n\u2009=\u200975), followed by multivariate analyses. The total dose was represented as an equivalent dose in 2-Gy fractions (EQD2) with \u03b1\/\u03b2\u2009=\u20093\u2009Gy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a median follow-up of 63\u2009months, the cumulative rates of 5-year late grade \u22652 GU and GI toxicities were 14% and 2.5%, respectively. The cumulative rates of 5-year late grade \u22652 GU toxicity in the \u22652.1\u2009Gy\/fraction and \u22642.0\u2009Gy\/fraction groups were 22% and 10%, respectively (P\u2009=\u2009.020). In the multivariate analysis, \u22652.1\u2009Gy\/fraction was still associated with an increased risk of late grade \u22652 GU toxicity (hazard ratio, 2.37; 95% confidence interval, 1.12-4.99; P\u2009=\u2009.023), while the total dose was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present results showed that \u22652.1\u2009Gy\/fraction resulted in a higher incidence of late grade \u22652 GU toxicity in SRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>The impact of fraction doses on late GU toxicity after SRT remains unknown. The results suggest that higher fraction doses may increase the risk of late GU toxicity in SRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqae055","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T16:03:56Z","timestamp":1710173036000},"page":"1050-1056","source":"Crossref","is-referenced-by-count":2,"title":["Late genitourinary toxicity in salvage radiotherapy for prostate cancer after radical prostatectomy: impact of daily fraction doses"],"prefix":"10.1093","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-9923","authenticated-orcid":false,"given":"Seiya","family":"Takano","sequence":"first","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Aichi 467-8601, 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467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-2974","authenticated-orcid":false,"given":"Akira","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Aichi 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-4637","authenticated-orcid":false,"given":"Nozomi","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Aichi 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Aichi 467-8601, 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