{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:54:27Z","timestamp":1757310867344,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1159","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our aim is to estimate the long-term neurological sequelae and prognosis in term neonatal asphyxia treated with hypothermia via volumetric apparent diffusion coefficient (ADC) map histogram analysis (HA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Brain MRI studies of 83 term neonates with asphyxia who received whole-body hypothermia treatment and examined between postnatal (PN) fourth and sixth days were retrospectively re-evaluated by 2 radiologists. Volumetric HA was performed for the areas frequently affected in deep and superficial asphyxia (thalamus, lentiform nucleus, posterior limb of internal capsule, corpus callosum forceps major, and perirolandic cortex-subcortical white matter) on ADC map. The quantitative ADC values were obtained separately for each region. Qualitative-visual (conventional) MRI findings were also re-evaluated. Neonates were examined neurodevelopmentally according to the Revised Brunet-Lezine scale. The distinguishability of long-term neurodevelopmental outcomes was statistically investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With HA, the adverse neurodevelopmental outcomes could only be distinguished from mild-moderated impairment and normal development at the thalamus with 10th percentile ADC (P\u2009=\u2009.02 and P\u2009=\u2009.03, respectively) and ADCmin (P\u2009=\u2009.03 and P\u2009=\u2009.04, respectively). Also with the conventional MRI findings, adverse outcome could be distinguished from mild-moderated impairment (P\u2009=\u2009.04) and normal development (P\u2009=\u2009.04) via cytotoxic oedema of the thalamus, corpus striatum, and diffuse cerebral cortical.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The long-term adverse neurodevelopmental outcomes in newborns with asphyxia who received whole-body hypothermia treatment can be estimated similarly with volumetric ADC-HA and the conventional assessment of the ADC map.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>This study compares early MRI ADC-HA with neurological sequelae in term newborns with asphyxia who received whole-body hypothermia treatment. We could not find any significant difference in predicting adverse neurological sequelae between the visual-qualitative evaluation of the ADC map and HA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqae105","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T16:30:39Z","timestamp":1716395439000},"page":"1302-1310","source":"Crossref","is-referenced-by-count":1,"title":["Volumetric apparent diffusion coefficient histogram analysis in term neonatal asphyxia treated with hypothermia"],"prefix":"10.1093","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4058","authenticated-orcid":false,"given":"Turgut","family":"Seber","sequence":"first","affiliation":[{"name":"Department of Radiology, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"Uylar Seber","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Ba\u015ftu\u011f","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015euayip","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Child Health and Diseases, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kayseri City Education and Research Hospital , Kayseri 38080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"issue":"1","key":"2024061918454163800_tqae105-B1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1542\/peds.109.1.26","article-title":"Early developmental outcomes after newborn encephalopathy","volume":"109","author":"Dixon","year":"2002","journal-title":"Pediatrics"},{"key":"2024061918454163800_tqae105-B2","volume-title":"Neurology of the Newborn","author":"Volpe","year":"2008","edition":"5th ed."},{"issue":"1","key":"2024061918454163800_tqae105-B3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(09)70295-9","article-title":"Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial","volume":"9","author":"Rutherford","year":"2010","journal-title":"Lancet Neurol"},{"issue":"14","key":"2024061918454163800_tqae105-B4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy [published correction appears in N Engl J Med. 2010;362(11):1056]","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"2024061918454163800_tqae105-B5","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"2024061918454163800_tqae105-B6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.1993.03510030084039","article-title":"Evolving toward effective therapy for acute ischemic stroke","volume":"270","author":"Fisher","year":"1993","journal-title":"JAMA"},{"issue":"4","key":"2024061918454163800_tqae105-B7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/01.STR.26.4.602","article-title":"Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. 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