{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:35:38Z","timestamp":1791304538347,"version":"4.3.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1164","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Youth Fund of National Natural Science Foundation of China","award":["82001900"],"award-info":[{"award-number":["82001900"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-003"],"award-info":[{"award-number":["2022-PUMCH-A-003"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-051"],"award-info":[{"award-number":["2021-I2M-1-051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the bone age (BA) characteristics of children living in high-altitude regions and determine the impact of altitude on the development of BA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From June 2014 to July 2022, 1318 children with left-hand-wrist radiographs were retrospectively enrolled from 3 different geographical altitudes (Beijing 43.5\u2009m above sea level [asl], Lhasa 3650\u2009m asl, and Nagqu 4500\u2009m asl). The predicted age difference (PAD), defined as the difference between BA and chronologic age (CA), was considered the indicator for delayed or advanced growth. The PAD of children from the 3 regions in total and according to different age groups, genders, and ethnicities were compared. The linear regression model was used to assess the effect of altitude on PAD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1284 children (CA: 12.00 [6.45-15.72] years; male: 837\/1284, 65.2%) were included in the study with 407 from Beijing, 491 from Lhasa, and 386 from Nagqu. The PAD for Beijing, Lhasa, and Nagqu were 0.1 [\u22120.30 to 0.65], \u22120.40 [\u22121.20 to 0.27], and \u22121.42 [\u22122.32 to \u22120.51] years, respectively. A linear regression analysis showed that altitude significantly contributed to PAD (compared to Beijing, Lhasa coefficient\u2009=\u2009\u22120.57, P\u2009&amp;lt;\u2009.001; Nagqu coefficient\u2009=\u2009\u22121.55, P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High altitude might be an independent contributor to the delayed BA development of children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>The impact of altitude on BA development was revealed for the first time, highlighting the necessity of considering the altitude of the area when evaluating BA development for children residing in high-altitude regions.ke<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqae168","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T15:51:18Z","timestamp":1724514678000},"page":"1931-1938","source":"Crossref","is-referenced-by-count":3,"title":["Children\u2019s bone age development is delayed with increasing altitude: a multicentre study"],"prefix":"10.1093","volume":"97","author":[{"given":"Qixing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100730,","place":["China"]},{"name":"School of Medicine, Tsinghua University , Beijing, 100084,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cidan","family":"Wangjiu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tibet Autonomous Region People\u2019s Hospital , Lhasa, 850000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudan","family":"Awang","sequence":"additional","affiliation":[{"name":"Department of Radiology, People's Hospital of Nyima County , Nagqu, 852000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, People's Hospital of Nyima County , Nagqu, 852000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puqiong","family":"Qiongda","sequence":"additional","affiliation":[{"name":"Department of Radiology, People's Hospital of Nagqu , Nagqu, 852000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huogen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer Science and Technology, Zhejiang University , Hangzhou, 310000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100730,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-7634","authenticated-orcid":false,"given":"Fengdan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 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