{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:01:27Z","timestamp":1790564487124,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1165","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical Mandate of Foundation","award":["FAF-C\/2018\/1190"],"award-info":[{"award-number":["FAF-C\/2018\/1190"]}]},{"name":"Clinical Mandate of Foundation","award":["C_2020_1377"],"award-info":[{"award-number":["C_2020_1377"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Deep inspiration breath-holds (DIBHs) reduce heart and lung toxicity during breast cancer radiotherapy. Consecutive DIBHs are stressful, time-consuming, and leads to position changes. To facilitate the introduction of pre-oxygenation using high-flow nasal oxygen (HFNO) and hyperventilation to prolong DIBHs (L-DIBHs), we examined the effect of hyperventilation time on the duration of L-DIBHs. Additionally, to minimize total treatment time, the feasibility of several successive L-DIBHs was examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Our previous protocol imposed 3\u2009min of hyperventilation at 16 breaths per minute with pre-oxygenation using HFNO, in prone position. In the first phase, the effect of hyperventilation time on the length of the L-DIBH was investigated. The aim of the second phase was to investigate the feasibility of shorter preparation times before the second and third L-DIBH in the case of 3 consecutive L-DIBHs of at least 2\u2009minutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There is a positive but weak correlation between preparation time and L-DIBH duration. With either 3\u2009minutes 30\u2009seconds or 6\u2009minutes 20\u2009seconds (depending on fitness) of voluntary hyperventilation duration, 93% of subjects could hold 3 consecutive L-DIBHs for over 2\u2009minutes. The median duration of the third and last L-DIBH was 3\u2009minutes 17\u2009seconds (SD 1\u2009min 4\u2009seconds).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A weak relationship exists between the hyperventilation time and L-DIBH duration. Repeating L-DIBHs with shorter preparations is achievable, resulting in a shorter total treatment time required.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>It is possible to perform repeated L-DIBHs for breast cancer irradiation using HFNO and hyperventilation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqae223","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T16:43:14Z","timestamp":1731429794000},"page":"45-49","source":"Crossref","is-referenced-by-count":2,"title":["Minimizing preparation time for repeated prolonged deep-inspiration breath holds during breast cancer irradiation using pre-oxygenation with high-flow nasal oxygen and voluntary hyperventilation"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7547-1304","authenticated-orcid":false,"given":"Vincent","family":"Vakaet","sequence":"first","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Radiation Oncology, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-2407","authenticated-orcid":false,"given":"Hans","family":"Van Hulle","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1615-5564","authenticated-orcid":false,"given":"Ren\u00e9e","family":"De Noyette","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-4518","authenticated-orcid":false,"given":"Max","family":"Schoepen","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Industrial Systems Engineering and Product Design , Kortrijk, 8500 Kortrijk,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-9847","authenticated-orcid":false,"given":"Pieter","family":"Deseyne","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Groningen, University of Groningen , Groningen, 9713 Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-7498","authenticated-orcid":false,"given":"Els","family":"Van Caelenberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Basic and Applied Medical Sciences, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Van Greveling","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Radiation Oncology, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-7313","authenticated-orcid":false,"given":"Chris","family":"Monten","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Radiation Oncology, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8862-4699","authenticated-orcid":false,"given":"Luc","family":"De Baerdemaeker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Basic and Applied Medical Sciences, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-064X","authenticated-orcid":false,"given":"Wilfried","family":"De Neve","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair, Ghent University , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-7154","authenticated-orcid":false,"given":"Marc","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]},{"name":"Department of Basic and Applied Medical Sciences, Ghent University Hospital , 9000 Ghent,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-2687","authenticated-orcid":false,"given":"Liv","family":"Veldeman","sequence":"additional","affiliation":[{"name":"Department of 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