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Using rapid cooling to as low as -200\u00b0C (at the tip of the probe), reliable, and predictable necrosis can be induced. Probes are usually percutaneously inserted under CT guidance under sedation or general anaesthesia, often as a day case. The procedure is safe with severe complications occurring rarely; the commonest complication is neural injury in lesions closely related to neurovascular bundles. Cryotherapy has been applied to the symptomatic and occasionally curative treatment of bone metastases and a range of primary bone lesions. This review summarizes the published evidence base for the use of cryotherapy in metastatic and primary bone lesions and describes the experience with cryotherapy at the Royal Orthopaedic Hospital, Birmingham, a quaternary bone tumour referral hospital, where cryotherapy has been used for 3\u2009years.<\/jats:p>","DOI":"10.1093\/bjr\/tqaf007","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:10:08Z","timestamp":1736986208000},"page":"851-860","source":"Crossref","is-referenced-by-count":1,"title":["Bone lesion cryotherapy: pictorial review and review of current evidence"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2882-6923","authenticated-orcid":false,"given":"Nathan","family":"Jenko","sequence":"first","affiliation":[{"name":"Department of Radiology, Royal Orthopaedic Hospital , Birmingham B31 2AP,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Orthopaedic Hospital , Birmingham B31 2AP,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish T","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Orthopaedic Hospital , Birmingham B31 2AP,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"2025052713303952300_tqaf007-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cryobiol.2013.11.001","article-title":"Mechanisms of cryoablation: clinical consequences on malignant tumors","volume":"68","author":"Baust","year":"2014","journal-title":"Cryobiology"},{"key":"2025052713303952300_tqaf007-B2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/cryo.1997.2039","article-title":"A comparative laboratory 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