{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:03:27Z","timestamp":1792785807006,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1170","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Special Program for Diagnosis and Treatment Technology of Clinical Key Diseases in Suzhou","award":["LCZX202001"],"award-info":[{"award-number":["LCZX202001"]}]},{"name":"Medical and Health Science and Technology Innovation Program in Suzhou","award":["SKY2022003"],"award-info":[{"award-number":["SKY2022003"]}]},{"name":"Suzhou Medical Association","award":["2023YX-M01"],"award-info":[{"award-number":["2023YX-M01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the value of on-site deep learning-based CT-derived fractional flow reserve (CT-FFR) for therapeutic management and adverse clinical outcomes in patients suspected of coronary artery disease (CAD) compared with coronary CT angiography (CCTA) alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-centre prospective study included consecutive patients suspected of CAD between June 2021 and September 2021 at our hospital. Four hundred and sixty-one patients were randomized into either CT-FFR+CCTA or CCTA-alone group. The first endpoint was the invasive coronary angiography (ICA) efficiency, defined as the ICA with nonobstructive disease (stenosis &amp;lt;50%) and the ratio of revascularization to ICA (REV-to-ICA ratio) within 90\u2009days. The second endpoint was the incidence of major adverse cardiaovascular events (MACE) at 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 461 patients (267 [57.9%] men; median age, 64 [55-69]) were included. At 90\u2009days, the rate of ICA with nonobstructive disease in the CT-FFR+CCTA group was lower than in the CCTA group (14.7% vs 34.0%, P=.047). The REV-to-ICA ratio in the CT-FFR+CCTA group was significantly higher than in the CCTA group (73.5% vs. 50.9%, P=.036). No significant difference in ICA efficiency was found in intermediate stenosis (25%-69%) between the 2 groups (all P&amp;gt;.05). After a median follow-up of 23 (22-24) months, MACE were observed in 11 patients in the CT-FFR+CCTA group and 24 in the CCTA group (5.9% vs 10.0%, P=.095).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The on-site deep learning-based CT-FFR improved the efficiency of ICA utilization with a similarly low rate of MACE compared with CCTA alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>The on-site deep learning-based CT-FFR was superior to CCTA for therapeutic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf055","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:01:08Z","timestamp":1742428868000},"page":"956-964","source":"Crossref","is-referenced-by-count":5,"title":["CT-derived fractional flow reserve on therapeutic management and outcomes compared with coronary CT angiography in coronary artery disease"],"prefix":"10.1093","volume":"98","author":[{"given":"Ying","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University , Suzhou 215006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University , Suzhou 215006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-758X","authenticated-orcid":false,"given":"Chunhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University , Suzhou 215006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University , Suzhou 215006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"2025052713282454200_tqaf055-B1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/S0140-6736(18)31891-9","article-title":"Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Dicker","year":"2018","journal-title":"Lancet"},{"key":"2025052713282454200_tqaf055-B2","doi-asserted-by":"crossref","first-page":"e005375","DOI":"10.1161\/CIRCOUTCOMES.118.005375","article-title":"Mortality from ischemic heart 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