{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:30:56Z","timestamp":1778344256566,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1170","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":69,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/TA\/0024\/2013"],"award-info":[{"award-number":["NMRC\/TA\/0024\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/TCR14\/012"],"award-info":[{"award-number":["NMRC\/TCR14\/012"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSI\/0006\/2006"],"award-info":[{"award-number":["NMRC\/CSI\/0006\/2006"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSASI\/0008\/2020"],"award-info":[{"award-number":["NMRC\/CSASI\/0008\/2020"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The splenial angle (SA), measured on axial DTI colour fractional anisotropy MRI, outperformed the callosal angle (CA) in predicting idiopathic normal pressure hydrocephalus (NPH) patients from those with Alzheimer\u2019s dementia, Parkinson\u2019s disease (PD), and healthy controls (HC). We investigated its reliability and classification performance on more commonly acquired T1 magnetization-prepared rapid gradient-echo (MPRAGE) and fluid-attenuated inversion-recovery (FLAIR) images.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Splenial angle was measured on axial MPRAGE and FLAIR images in 57 subjects (19 NPH, PD and HC each) by 2 raters and compared across groups. Receiver operating characteristics (ROC) analysis was used to assess its classification performance, differentiating NPH from non-NPH groups, in comparison to the CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Inter-rater reliability for SA was excellent (intraclass correlation coefficients \u2265 0.91). Splenial angle was effective in differentiating NPH from non-NPH patients on MPRAGE and FLAIR images (P\u2009&amp;lt;\u2009.001). Its ROC curves showed excellent performance classifying NPH from HC (Area under the curve [AUC] 1) and PD (AUC &amp;gt; 0.93) groups and were highly comparable to those for CA (1; 0.947). Angles wider than 60\u00b0 and narrower than 45\u00b0 robustly (100%) excluded and predicted NPH from HC, respectively. The narrower 45\u00b0 cutoff yielded better sensitivity (84.2%-89.5%) in differentiating NPH from PD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SA on MPRAGE\/FLAIR images showed excellent inter-rater reliability and classification performance predicting NPH from non-NPH groups, rivalling those of the CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>The SA on MPRAGE and FLAIR images is reproducible and shows excellent diagnostic performance, differentiating NPH from non-NPH groups, with potential to replace the CA in NPH screening given its accessibility on routine axial neuroimaging.<\/jats:p>\n               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169857,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeet","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, National Neuroscience Institute , Singapore 308433,","place":["Singapore"]},{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiling","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiography, Singapore General Hospital , Singapore 169608,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihua","family":"Li","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]},{"name":"National Dental Centre , Singapore 168938,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis C S","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]},{"name":"Department of Neurology, National Neuroscience Institute , Singapore 308433,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng King","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]},{"name":"Department of Neurology, National Neuroscience Institute , Singapore 308433,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole C H","family":"Keong","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]},{"name":"Department of Neurosurgery, National Neuroscience Institute , Singapore 308433,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7334","authenticated-orcid":false,"given":"Ling Ling","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Singapore General Hospital , Singapore 169608,","place":["Singapore"]},{"name":"Department of Neuroradiology, National Neuroscience Institute , Singapore 308433,","place":["Singapore"]},{"name":"Duke-NUS Medical School , Singapore 169857,","place":["Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"2025052713265406400_tqaf058-B1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2176\/nmc.st.2020-0292","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus (third edition): endorsed by the Japanese society of normal pressure 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