{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:02:09Z","timestamp":1793318529250,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1176","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Society of Cancer in Children and Adolescents"},{"DOI":"10.13039\/501100016037","name":"Gustave Roussy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016037","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Paediatric Program \u201cGu\u00e9rir le Cancer de l\u2019Enfant\u201d"},{"name":"Foundation ARC"},{"DOI":"10.13039\/100000054","name":"National Institute of Cancer","doi-asserted-by":"crossref","award":["SHS-RISP22-014"],"award-info":[{"award-number":["SHS-RISP22-014"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000163","name":"ARC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000163","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to describe pregnancy and maternal outcomes according to radiation doses received to the uterus during photon beam therapy in the French Childhood Cancer Survivor Study (FCCSS) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of the 7670 5-years survivors, 1159 women treated by radiotherapy and with no hysterectomy, followed between 2006 and 2018 were included. Uterus dose were reconstructed within phantoms modelling patient\u2019s anatomy in treatment position. A statistical analysis was performed including demographic information, treatment variables, and co-factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1159 women, 297 (25.6%) had at least 1 pregnancy, of whom 105\/297 (35.3%) had a uterine dose of Dmedian &amp;gt; 1Gy. The proportion of ectopic pregnancy, spontaneous and medical abortions was 20.3% (101\/498) and increased to 39% if Dmedian_uterus &amp;gt; 20Gy, versus 12% reported in the French\u2019s general population. When medical pregnancy terminations were excluded, significant associations with an increase in risks were found for women who were older than 40 at the time of pregnancy and Dmedian_uterus &amp;gt; 20Gy. Two women whose entire uterus received over 40\u2009Gy had 1 pregnancy, resulting in a live birth. One woman passed away due to haemorrhage during delivery, treated at age 16 with D80%uterus = 35Gy. No other delivery-related deaths were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Assessing the dose to the uterus for pelvic irradiation treatments is necessary, and volume receiving 20\u2009Gy should be minimized. Even if pregnancy is feasible after really high dose received on the uterus (Dmean &amp;gt; 40Gy), a close obstetrical monitoring is recommended, and home delivery should be contraindicated due to the risk of vital haemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This article provides valuable data between radiation dose to the uterus and pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf130","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:33:46Z","timestamp":1758328426000},"page":"2079-2089","source":"Crossref","is-referenced-by-count":4,"title":["Pregnancy outcomes in childhood cancer survivors according to uterine radiation dose and other factors"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-6035","authenticated-orcid":false,"given":"Christophe","family":"Legrand","sequence":"first","affiliation":[{"name":"Department of Medical Physics, Institut de Canc\u00e9rologie de l\u2019Ouest , Angers 49100,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bolle","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Radiation Oncology, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-4831","authenticated-orcid":false,"given":"Francois","family":"Doz","sequence":"additional","affiliation":[{"name":"SIREDO Centre (Care, Innovation, Research in Pediatric, Adolescent and Young Adults Oncology), Institut Curie and University Paris Cit\u00e9 , Paris 75005,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-6660","authenticated-orcid":false,"given":"Vassilis","family":"Tsatsaris","sequence":"additional","affiliation":[{"name":"Maternit\u00e9 Port Royal, H\u00f4pital Cochin, Universit\u00e9 Ren\u00e9 Descartes , Paris 75014,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology, Necker-Enfants Malades Hospital, APHP, Universit\u00e9 Paris Cit\u00e9 , Paris 75015,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7828","authenticated-orcid":false,"given":"Brice","family":"Fresneau","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Children and Adolescent Oncology, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-5815","authenticated-orcid":false,"given":"Claire","family":"Alapetite","sequence":"additional","affiliation":[{"name":"Institut Curie, Radiation Oncology Department, Paris & Proton Center , Orsay 91400,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Helfre","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Institut Curie , Paris 75005,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-7935","authenticated-orcid":false,"given":"Anne","family":"Laprie","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud\u2014Institut Universitaire du Cancer de Toulouse-Oncopole , Toulouse 31059,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Bondiau","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Antoine Lacassagne Center , Nice 06189,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-8441","authenticated-orcid":false,"given":"Monia","family":"Zidane","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigue","family":"Allodji","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Haddy","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neige","family":"Journy","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Boussac","sequence":"additional","affiliation":[{"name":"French National Health Insurance (CNAM) , Paris 75986,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Thomas-Teinturier","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"AP-HP, H\u00f4pital Bic\u00eatre, Department of Pediatric Endocrinology and Diabetes , Paris 94270,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-8817","authenticated-orcid":false,"given":"Ibrahima","family":"Diallo","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]},{"name":"Inserm, UMR 1030 , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Veres","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Gustave Roussy , Villejuif 94800,","place":["France"]},{"name":"Universit\u00e9 Paris-Saclay, Institut Gustave Roussy, Inserm, Radioth\u00e9rapie Mol\u00e9culaire et Innovation Th\u00e9rapeutique , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Souchard","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giao","family":"Vu-Bezin","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-9281","authenticated-orcid":false,"given":"Florent","family":"De Vathaire","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Research, Gustave Roussy , Villejuif 94800,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-9089","authenticated-orcid":false,"given":"Charlotte","family":"Demoor-Goldschmidt","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Team, CESP, INSERM U1018 , Villejuif 94800,","place":["Franc e"]},{"name":"Department of Pediatric Onco-Hematology, University Hospital of Angers , Angers 49000,","place":["France"]},{"name":"Department of Pediatric Onco-Hematology, University Hospital of Caen , Caen 14000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2026011615171120500_tqaf130-B1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International incidence of childhood cancer. 2001\u201310: a population-based registry study","volume":"18","author":"Steliarova-Foucher","year":"2017","journal-title":"Lancet Oncol"},{"key":"2026011615171120500_tqaf130-B2","volume-title":"Childhood Cancer Survivorship: Improving Care and Quality of Life","author":"Hewitt","year":"2003"},{"key":"2026011615171120500_tqaf130-B3","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"2026011615171120500_tqaf130-B4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/CEJ.0000000000000006","article-title":"Childhood cancer survival in France. 2000-2008","volume":"23","author":"Lacour","year":"2014","journal-title":"Eur J Cancer Prev"},{"key":"2026011615171120500_tqaf130-B5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/ajco.12700","article-title":"Models of childhood cancer survivorship care in Australia and New Zealand: strengths and challenges","volume":"13","author":"Signorelli","year":"2017","journal-title":"Asia Pac J Clin Oncol"},{"key":"2026011615171120500_tqaf130-B6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0140-6736(10)60752-0","article-title":"Stillbirth and neonatal death in relation to radiation exposure before conception: a retrospective cohort study","volume":"376","author":"Signorello","year":"2010","journal-title":"Lancet"},{"key":"2026011615171120500_tqaf130-B7","doi-asserted-by":"crossref","first-page":"482968","DOI":"10.1155\/2014\/482968","article-title":"The impact of uterine radiation on subsequent fertility and pregnancy outcomes","volume":"2014","author":"Teh","year":"2014","journal-title":"Biomed Res Int"},{"key":"2026011615171120500_tqaf130-B8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.ijrobp.2009.04.012","article-title":"Fertility and pregnancy outcome after abdominal irradiation that included or excluded the pelvis in childhood tumour survivors","volume":"76","author":"Sudour","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026011615171120500_tqaf130-B9","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/humrep\/deq029","article-title":"Pregnancy outcome in female childhood cancer survivors","volume":"25","author":"Lie Fong","year":"2010","journal-title":"Hum Reprod"},{"key":"2026011615171120500_tqaf130-B10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ajog.2020.05.058","article-title":"Counseling and surveillance of obstetrical risks for female childhood. adolescent and young adults cancer survivors: recommendations from the international late effects of childhood cancer guideline harmonization group","volume":"1","author":"Van der","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"2026011615171120500_tqaf130-B11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/jncimonographs\/lgi022","article-title":"Impact of cancer treatment on uterine function","author":"Critchley","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026011615171120500_tqaf130-B12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/jama.1987.03390020082031","article-title":"Outcome of pregnancy in survivors of Wilms\u2019 tumour","volume":"257","author":"Li","year":"1987","journal-title":"JAMA"},{"key":"2026011615171120500_tqaf130-B13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1471-0528.1989.tb02408.x","article-title":"Pregnancies after childhood cancer","volume":"96","author":"Smith","year":"1989","journal-title":"Br J Obstet Gynaecol"},{"key":"2026011615171120500_tqaf130-B14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ijc.2910430309","article-title":"Pregnancy outcomes in childhood cancer survivors: probable effects of abdominal irradiation","volume":"43","author":"Hawkins","year":"1989","journal-title":"Int J Cancer"},{"key":"2026011615171120500_tqaf130-B15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.fertnstert.2018.11.026","article-title":"Future fertility in survivors of childhood cancer-examining the impact of cancer treatment on uterus function","volume":"111","author":"Rodriguez-Wallberg","year":"2019","journal-title":"Fertil Steril"},{"key":"2026011615171120500_tqaf130-B16","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.6004\/jnccn.2018.7023","article-title":"Management of primary ovarian insufficiency symptoms in survivors of childhood and adolescent cancer","volume":"16","author":"Gargus","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"key":"2026011615171120500_tqaf130-B17","first-page":"23","article-title":"Late effects of abdominal-pelvic radiation therapy on fertility in women under the age of 30: a literature review","volume":"53","author":"Borrie","year":"2010","journal-title":"Shadows"},{"key":"2026011615171120500_tqaf130-B18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/humupd\/dmz041","article-title":"Do cancer therapies damage the uterus and compromise fertility?","volume":"26","author":"Griffiths","year":"2020","journal-title":"Hum Reprod Update"},{"key":"2026011615171120500_tqaf130-B19","first-page":"483","article-title":"Solid malignant neoplasms after childhood irradiation: decrease of the relative risk with time after irradiation","author":"De Vathaire","year":"1995","journal-title":"C. R. Acad. Sci"},{"key":"2026011615171120500_tqaf130-B20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/CIRCULATIONAHA.115.016686","article-title":"Cardiac diseases following childhood cancer treatment: cohort study","volume":"133","author":"Haddy","year":"2016","journal-title":"Circulation"},{"key":"2026011615171120500_tqaf130-B21","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1016\/j.respe.2017.05.004","article-title":"Value of a national administrative database to guide public decisions: from the syst\u00e8me national d\u2019information interr\u00e9gimes de l\u2019Assurance maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France","volume":"65","author":"Tuppin","year":"2017","journal-title":"Rev Epidemiol Sante Publique"},{"key":"2026011615171120500_tqaf130-B22","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1088\/0031-9155\/60\/5\/2103","article-title":"Field size dependent mapping of medical linear accelerator radiation leakage","volume":"60","author":"Bezin","year":"2015","journal-title":"Phys Med Biol"},{"key":"2026011615171120500_tqaf130-B23","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.ijrobp.2014.08.335","article-title":"Retrospective reconstructions of active bone marrow dose-volume histograms","volume":"90","author":"Veres","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026011615171120500_tqaf130-B24","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/1361-6498\/aa575d","article-title":"A review of uncertainties in radiotherapy dose reconstruction and their impacts on dose\u2013response relationships","volume":"37","author":"V\u0169 Bezin","year":"2017","journal-title":"J Radiol Prot"},{"key":"2026011615171120500_tqaf130-B25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/pbc.24679","article-title":"The cyclophosphamide equivalent dose as an approach for quantifying alkylating agent exposure: a report from the childhood cancer survivor study","volume":"61","author":"Green","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"2026011615171120500_tqaf130-B26","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1200\/JCO.2008.20.1541","article-title":"Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study","volume":"27","author":"Green","year":"2009","journal-title":"J Clin Oncol"},{"key":"2026011615171120500_tqaf130-B27","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S1470-2045(24)00269-9","article-title":"Risks of adverse obstetric outcomes among female survivors of adolescent and young adult cancer in England (TYACSS): a population-based, retrospective cohort study","volume":"25","author":"Sunguc","year":"2024","journal-title":"Lancet Oncol"},{"key":"2026011615171120500_tqaf130-B28","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1016\/S1470-2045(24)00512-6","article-title":"Adverse obstetric outcomes in female survivors of adolescent and young adult cancers\u2014authors\u2019 reply","volume":"25","author":"Reulen","year":"2024","journal-title":"Lancet Oncol"},{"key":"2026011615171120500_tqaf130-B29","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/s41416-024-02818-0","article-title":"Live birth and maternity outcome in childhood and adolescent cancer survivors under 18 years at diagnosis: a 40-year population-based cohort study","volume":"131","author":"Wallace","year":"2024","journal-title":"Br J Cancer"},{"key":"2026011615171120500_tqaf130-B30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41416-023-02333-8","article-title":"Cancer survivorship and risk of pregnancy complications, adverse obstetric outcomes, and maternal morbidities in female adolescents and young adults: a nationwide population-based study from Taiwan","volume":"129","author":"Kao","year":"2023","journal-title":"Br J Cancer"},{"key":"2026011615171120500_tqaf130-B31","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"2026011615171120500_tqaf130-B32","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jgyn.2014.09.011","article-title":"Epidemiology of loss pregnancy","volume":"43","author":"Delabaere","year":"2014","journal-title":"J Gynecol Obstet Hum Reprod"},{"key":"2026011615171120500_tqaf130-B33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/1464727022000198942","article-title":"Radiation damage to the uterus\u2014review of the effects of treatment of childhood cancer","volume":"5","author":"Critchley","year":"2002","journal-title":"Hum Fertil (Camb)"},{"key":"2026011615171120500_tqaf130-B34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0412.2004.00332.x","article-title":"Radiotherapy at a young age reduces uterine volume of childhood cancer survivors","volume":"83","author":"Larsen","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026011615171120500_tqaf130-B35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1634\/theoncologist.2017-0201","article-title":"Ovarian and uterine functions in female survivors of childhood cancers","volume":"23","author":"Oktem","year":"2018","journal-title":"Oncologist"},{"key":"2026011615171120500_tqaf130-B36","doi-asserted-by":"crossref","first-page":"e163704","DOI":"10.1172\/jci.insight.163704","article-title":"Radiotherapy exposure directly damages the uterus and causes pregnancy loss","volume":"8","author":"Griffiths","year":"2023","journal-title":"JCI Insight"},{"key":"2026011615171120500_tqaf130-B37","doi-asserted-by":"crossref","first-page":"e0157375","DOI":"10.1371\/journal.pone.0157375","article-title":"A validated normative model for human uterine volume from birth to age 40 years","volume":"11","author":"Kelsey","year":"2016","journal-title":"PLoS One"},{"key":"2026011615171120500_tqaf130-B38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1200\/JCO.2011.35.0504","article-title":"Genetic disease in the children of Danish survivors of childhood and adolescent cancer","volume":"30","author":"Winther","year":"2012","journal-title":"J Clin Oncol"},{"key":"2026011615171120500_tqaf130-B39","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.1999.tb08180.x","article-title":"Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: response to sex steroid replacement","volume":"106","author":"Bath","year":"1999","journal-title":"Br J Obstet Gynaecol"},{"key":"2026011615171120500_tqaf130-B40","first-page":"259","article-title":"Ultrasound B-mode changes in the uterus and ovaries and Doppler changes in the uterus after total body irradiation and allogeneic bone marrow transplantation in childhood","volume-title":"Bone Marrow Transplant","author":"Holm","year":"1999"},{"key":"2026011615171120500_tqaf130-B41"},{"key":"2026011615171120500_tqaf130-B42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejca.2019.01.104","article-title":"Perinatal complications in female survivors of cancer: a systematic review and meta-analysis","volume":"111","author":"Van der Kooi","year":"2019","journal-title":"Eur J Cancer"}],"container-title":["British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/advance-article-pdf\/doi\/10.1093\/bjr\/tqaf130\/64316564\/tqaf130.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/98\/1176\/2079\/64316564\/tqaf130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/98\/1176\/2079\/64316564\/tqaf130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:17:25Z","timestamp":1768594645000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/98\/1176\/2079\/8257683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":42,"journal-issue":{"issue":"1176","published-online":{"date-parts":[[2025,9,18]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bjr\/tqaf130","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,9,18]]}}}