{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:24:00Z","timestamp":1768634640621,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1176","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2010003"],"award-info":[{"award-number":["2022YFC2010003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central guidance for Ningxia Hui Autonomous Region in 2023","award":["2023FRD05010"],"award-info":[{"award-number":["2023FRD05010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the impact of left ventricular myocardial fibrosis on left atrial function in patients with non-obstructive hypertrophic cardiomyopathy (NOHCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 103 NOHCM patients and 28 healthy controls (HC) were included retrospectively. Patients were stratified based on late gadolinium enhancement (LGE) into the following groups: NOHCM LGE (\u2212) group, mild LGE% (+) group (LGE% &amp;lt; 7%), moderate LGE% (+) group (7% \u2264 LGE% &amp;lt; 15%), and severe LGE% (+) group (LGE% \u2265 15%). CMR-FT strain analysis assessed left atrial strain and strain rate across different cardiac phases. Statistical analyses for clinical and imaging parameters, and Spearman correlation analysis for assessing correlations between left ventricular myocardial fibrosis and left atrial volume and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no significant differences in left atrial function and volume parameters between the LGE (\u2212) group and the mild LGE% (+) group. However, \u03b5s, \u03b5e, SRs, and SRe showed gradual decreases across mild, moderate, and severe LGE% (+) groups, with significant differences observed among the 3 groups. \u03b5a and SRa in the moderate and severe LGE% (+) groups were significantly lower than those in the mild LGE% (+) group. There are strong correlations between the degree of left ventricular myocardial fibrosis and LAEF, LAEDV, LAESV, \u03b5s, \u03b5e, \u03b5a, SRs, SRe, and SRa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>As left ventricular myocardial fibrosis progressed, left atrial function deteriorated further, highlighting an interaction between left ventricular myocardial structure and left atrial function that promotes NOHCM progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>Complement the guidelines (2020 AHA\/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf135","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T07:40:34Z","timestamp":1758958834000},"page":"2090-2098","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between left ventricular myocardial fibrosis and left atrial dysfunction in patients with non-obstructive hypertrophic cardiomyopathy"],"prefix":"10.1093","volume":"98","author":[{"given":"Yan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology, General Hospital of Ningxia Medical University , Yichuan 750004,","place":["China"]},{"name":"The First Clinical Medical College of Ningxia Medical University , Yinchuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chengdu Second People\u2019s Hospital , Chengdu 610000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huairong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital of Ningxia Medical University , Yichuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Ningxia Medical University , Yinchuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital of Ningxia Medical University , Yichuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital of Ningxia Medical University , Yichuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4755-9246","authenticated-orcid":false,"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, General Hospital of Ningxia Medical University , Yichuan 750004,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"2026011615172170100_tqaf135-B1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.5152\/AnatolJCardiol.2022.1832","article-title":"Left atrial dysfunction as marker of arrhythmic events in patients with hypertrophic cardiomyopathy","volume":"26","author":"Candan","year":"2022","journal-title":"Anatol J Cardiol"},{"key":"2026011615172170100_tqaf135-B2","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1016\/j.jacc.2020.08.044","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026011615172170100_tqaf135-B3","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.5114\/pjr.2023.125213","article-title":"The association of left atrial mechanics with left ventricular morphology in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance study","volume":"88","author":"Guler","year":"2023","journal-title":"Pol J Radiol"},{"key":"2026011615172170100_tqaf135-B4","doi-asserted-by":"publisher","first-page":"719","DOI":"10.5152\/akd.2014.5101","article-title":"The left atrial phasic functions and the relationship with plasma N-terminal pro-B-type natriuretic peptide levels and symptomatic states in patients with hypertrophic cardiomyopathy","volume":"14","author":"T\u00fcl\u00fcce","year":"2014","journal-title":"Anadolu Kardiyol Derg"},{"key":"2026011615172170100_tqaf135-B5","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.amjcard.2017.02.002","article-title":"Impact of left ventricular diastolic property on left atrial function from simultaneous left atrial and ventricular three-dimensional echocardiographic volume measurement","volume":"119","author":"Yamano","year":"2017","journal-title":"Am J Cardiol"},{"key":"2026011615172170100_tqaf135-B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12968-019-0589-5","article-title":"Quantification of left atrial function in patients with non-obstructive hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking imaging: a feasibility and reproducibility study","volume":"22","author":"Yang","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011615172170100_tqaf135-B7","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1007\/s00330-014-3390-8","article-title":"Extent of late gadolinium enhancement at right ventricular insertion points in patients with hypertrophic cardiomyopathy: relation with diastolic dysfunction","volume":"25","author":"Zhu","year":"2015","journal-title":"Eur Radiol"},{"key":"2026011615172170100_tqaf135-B8","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1038\/s41467-024-48229-w","article-title":"Deep learning of left atrial structure and function provides link to atrial fibrillation risk","volume":"15","author":"Pirruccello","year":"2024","journal-title":"Nat Commun"},{"key":"2026011615172170100_tqaf135-B9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/jcu.23318","article-title":"Left atrial dysfunction as the major driver of heart failure with preserved ejection fraction syndrome","volume":"50","author":"Ovchinnikov","year":"2022","journal-title":"J Clin Ultrasound"},{"key":"2026011615172170100_tqaf135-B10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1148\/radiol.2019191385","article-title":"Left ventricular hypertrophy and late gadolinium enhancement at cardiac MRI are associated with adverse cardiac events in Fabry disease","volume":"294","author":"Hanneman","year":"2020","journal-title":"Radiology"},{"key":"2026011615172170100_tqaf135-B11","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1161\/CIRCIMAGING.113.001144","article-title":"Late gadolinium enhancement on cardiac magnetic resonance predicts adverse cardiovascular outcomes in nonischemic cardiomyopathy: a systematic review and meta-analysis","volume":"7","author":"Kuruvilla","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B12","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1148\/radiol.2021212214","article-title":"The clinical significance of cardiac MRI late gadolinium enhancement in hypertrophic cardiomyopathy","volume":"302","author":"Hanneman","year":"2022","journal-title":"Radiology"},{"key":"2026011615172170100_tqaf135-B13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/RLI.0000000000000326","article-title":"Left atrial performance in the course of hypertrophic cardiomyopathy: relation to left ventricular hypertrophy and fibrosis","volume":"52","author":"Kowallick","year":"2017","journal-title":"Invest Radiol"},{"key":"2026011615172170100_tqaf135-B14","doi-asserted-by":"publisher","first-page":"e0157433","DOI":"10.1371\/journal.pone.0157433","article-title":"Left atrial mechanical function and global strain in hypertrophic cardiomyopathy","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"2026011615172170100_tqaf135-B15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1161\/CIRCRESAHA.117.311059","article-title":"Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy","volume":"121","author":"Marian","year":"2017","journal-title":"Circ Res"},{"key":"2026011615172170100_tqaf135-B16","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1007\/s10554-019-01534-8","article-title":"Prognostic value of left atrial function by cardiovascular magnetic resonance feature tracking in hypertrophic cardiomyopathy","volume":"35","author":"Hinojar","year":"2019","journal-title":"Int J Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B17","doi-asserted-by":"publisher","first-page":"481245","DOI":"10.1155\/2015\/481245","article-title":"Effect of left ventricular outflow tract obstruction on left atrial mechanics in hypertrophic cardiomyopathy","volume":"2015","author":"Williams","year":"2015","journal-title":"Biomed Res Int"},{"key":"2026011615172170100_tqaf135-B18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s44156-024-00051-2","article-title":"The assessment of left ventricular diastolic function: guidance and recommendations from the British Society of Echocardiography","volume":"11","author":"Robinson","year":"2024","journal-title":"Echo Res Pract"},{"key":"2026011615172170100_tqaf135-B19","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1007\/s00330-020-06971-x","article-title":"Influence of contrast agent and spatial resolution on myocardial strain results using feature tracking MRI","volume":"30","author":"von Knobelsdorff-Brenkenhoff","year":"2020","journal-title":"Eur Radiol"},{"key":"2026011615172170100_tqaf135-B20","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/eurheartj\/ehv529","article-title":"Myocardial strain imaging: how useful is it in clinical decision making?","volume":"37","author":"Smiseth","year":"2016","journal-title":"Eur Heart J"},{"key":"2026011615172170100_tqaf135-B21","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1016\/j.jcmg.2019.01.044","article-title":"2- and 3-Dimensional myocardial strain in cardiac health and disease","volume":"12","author":"Voigt","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B22","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1007\/s00330-022-08629-2","article-title":"State-of-the-art myocardial strain by CMR feature tracking: clinical applications and future perspectives","volume":"32","author":"Xu","year":"2022","journal-title":"Eur Radiol"},{"key":"2026011615172170100_tqaf135-B23","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/j.jcmg.2023.07.003","article-title":"Left atrial function in cardiac amyloidosis","volume":"16","author":"Nagueh","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12968-015-0140-2","article-title":"Quantification of atrial dynamics using cardiovascular magnetic resonance: inter-study reproducibility","volume":"17","author":"Kowallick","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"key":"2026011615172170100_tqaf135-B25","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.jacc.2013.01.037","article-title":"Prevention of sudden cardiac death with implantable cardioverter-defibrillators in children and adolescents with hypertrophic cardiomyopathy","volume":"61","author":"Maron","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026011615172170100_tqaf135-B26","doi-asserted-by":"publisher","first-page":"132135","DOI":"10.1016\/j.ijcard.2024.132135","article-title":"Interstitial fibrosis is associated with left atrial remodeling and adverse clinical outcomes in selected low-risk patients with hypertrophic cardiomyopathy","volume":"408","author":"Tondi","year":"2024","journal-title":"Int J Cardiol"},{"key":"2026011615172170100_tqaf135-B27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12933-023-01997-z","article-title":"Assessment of left atrioventricular coupling and left atrial function impairment in diabetes with and without hypertension using CMR feature tracking","volume":"22","author":"Shi","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"2026011615172170100_tqaf135-B28","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s10741-022-10214-0","article-title":"Detection of myocardial fibrosis by speckle-tracking echocardiography: from prediction to clinical applications","volume":"27","author":"Lisi","year":"2022","journal-title":"Heart Fail Rev"},{"key":"2026011615172170100_tqaf135-B29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s41588-023-01371-5","article-title":"Genetics of myocardial interstitial fibrosis in the human heart and association with disease","volume":"55","author":"Nauffal","year":"2023","journal-title":"Nat Genet"},{"key":"2026011615172170100_tqaf135-B30","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.jcmg.2019.06.030","article-title":"Myocardial tissue characterization and fibrosis by imaging","volume":"13","author":"Karamitsos","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B31","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Authors\/Task Force Members","year":"2014","journal-title":"Eur Heart J"},{"key":"2026011615172170100_tqaf135-B32","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.jcmg.2016.07.015","article-title":"LA phasic volumes and reservoir function in the elderly by real-time 3D echocardiography: normal values, prognostic significance, and clinical correlates","volume":"10","author":"Russo","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026011615172170100_tqaf135-B33","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.echo.2005.06.011","article-title":"Enlarged left atrial volume in hypertrophic cardiomyopathy: a marker for disease severity","volume":"18","author":"Yang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"2026011615172170100_tqaf135-B34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12968-017-0420-0","article-title":"Left atrial structure and function in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy","volume":"19","author":"Farhad","year":"2017","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/advance-article-pdf\/doi\/10.1093\/bjr\/tqaf135\/64417395\/tqaf135.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/98\/1176\/2090\/64417395\/tqaf135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/98\/1176\/2090\/64417395\/tqaf135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T20:17:29Z","timestamp":1768594649000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/98\/1176\/2090\/8266698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,27]]},"references-count":34,"journal-issue":{"issue":"1176","published-online":{"date-parts":[[2025,9,27]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bjr\/tqaf135","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,9,27]]}}}