{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:11:18Z","timestamp":1756167078296,"version":"3.44.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1173","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical Research Program of 9th People's Hospital"},{"DOI":"10.13039\/501100008233","name":"Shanghai Jiao Tong University School of Medicine","doi-asserted-by":"publisher","award":["JYLJ202107"],"award-info":[{"award-number":["JYLJ202107"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To develop and validate a novel CT enterography (CTE)-based radiomics nomogram for predicting disease activity in Crohn\u2019s disease (CD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The CTE images and clinical data of 133 CD patients were retrospectively collected. The CTE-based radiomics features were extracted and screened by t-test and least absolute shrinkage and selection operator regression algorithm. Significant clinical variables were identified by multifactor logistic regression analysis. Then a combined model of clinical and radiomics features was established by multifactorial logistic regression, and a nomogram was plotted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>11 and 16 best radiomics features were screened based on CTE venous phase and arterial phase images, respectively. The area under ROC curve (AUC) of the venous radiomics model was higher than that of the arterial radiomics model on both the training and test sets (0.948 vs 0.927, 0.915 vs 0.878). Venous CT value, erythrocyte sedimentation rate and C-reactive protein were clinically relevant independent predictors of CD activity, and the AUC of the clinical model constructed from the 3 predictors was 0.873 and 0.822 on the training set and test set, respectively. The combined model had AUCs of 0.968 and 0.944 on the training and test sets, respectively. And the accuracy, sensitivity, and specificity were 0.900, 0.913, and 0.882 on the test set, respectively, which were higher than the other models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We develop a novel clinical radiomics nomogram to predict CD activity, which can assist clinicians in individualized treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>This study is a novel attempt to establish a combined clinical-imaging graph model to predict the CD activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf141","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T22:18:11Z","timestamp":1751149091000},"page":"1446-1455","source":"Crossref","is-referenced-by-count":0,"title":["A novel clinical radiomics nomogram to predict disease activity in Crohn\u2019s disease"],"prefix":"10.1093","volume":"98","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuhong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 200011,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-1144","authenticated-orcid":false,"given":"Yuanjun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Health Science and Engineering, University of Shanghai for Science and Technology , Shanghai, 200093,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"2025082513064535200_tqaf141-B1","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.3748\/wjg.v20.i12.3198","article-title":"Inflammatory bowel disease course in Crohn's disease: is the natural history changing?","volume":"20","author":"Golovics","year":"2014","journal-title":"WJG"},{"key":"2025082513064535200_tqaf141-B2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a crohn\u2019s disease activity index. 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