{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:48:58Z","timestamp":1776746938798,"version":"3.51.2"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1176","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Anaphylactic reactions are dramatic and life-threatening. According to international guidelines, the immediate intramuscular administration of adrenaline is the most important first step for acute management. The aim of this study is to determine whether doctors can recognize and treat severe anaphylactic reactions to contrast agents adequately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 95 doctors were interviewed between January and June 2023 in European clinics that are not affiliated with the authors. Ninety-five doctors from radiology, internal medicine, and anaesthesia departments were randomly selected for interviews. A video was prepared simulating a male patient developing a severe anaphylactic reaction during CT after intravenous administration of an iodinated contrast medium. After the video, 95 doctors were interviewed (59 radiologists, 19 internists, and 17 anaesthesiologists). The doctors were asked 3 questions: (1) What is the diagnosis? (2) What is the therapy of choice? (3) Can you demonstrate the correct way to operate the adrenaline autoinjector?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 95 doctors made the correct diagnosis (100%). Sixty-three of 95 physicians (66%) were uncertain regarding the appropriate first-line therapy. This was observed across all three medical specialties (internal medicine, anaesthesiology, and radiology) (P\u2009=\u2009.64). Sixty-five physicians (68%) had difficulties triggering the autoinjection system successfully.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute anaphylaxis is life-threatening, but there is uncertainty among professional groups about initiating acute management. Refresher training should be considered to ensure timely and appropriate treatment of the condition when it occurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This study highlighted significant gaps in physicians\u2019 real-world readiness to manage acute anaphylaxis, despite all doctors correctly diagnosing the condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf215","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:10:42Z","timestamp":1761757842000},"page":"2168-2174","source":"Crossref","is-referenced-by-count":1,"title":["Severe anaphylactic reaction to contrast agent: teams are well prepared but should simulate the situations regularly"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5161-5974","authenticated-orcid":false,"given":"Karl-Christian","family":"Pape","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]},{"name":"Department of Radiology and Nuclear Medicine, Kantonsspital Schaffhausen , 8208 Schaffhausen,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Meissnitzer","sequence":"additional","affiliation":[{"name":"Department of Radiology, R\u00f6ntgen Mirabell, Gruppenpraxis Radiologie , 5020 Salzburg,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Str\u00fcby","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sartoretti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Zurich , 8032 Zurich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]},{"name":"Department of Radiology, University Hospital Basel , 4031 Basel,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Matoori","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al , Montreal, QC H3T 1J4,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes M","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schindera","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kantonsspital Aarau , 5000 Aarau,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Laures","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kantonsspital Aarau , 5000 Aarau,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"H\u00e4lg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kantonsspital Aarau , 5000 Aarau,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Hergan","sequence":"additional","affiliation":[{"name":"Department of Radiology, R\u00f6ntgen Mirabell, Gruppenpraxis Radiologie , 5020 Salzburg,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hecht","sequence":"additional","affiliation":[{"name":"Department of Radiology, R\u00f6ntgen Mirabell, Gruppenpraxis Radiologie , 5020 Salzburg,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Luzerner Kantonsspital, Lucerne, 6000,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Allergy Unit, Zieglerspital, Clinic of Internal Medicine, Spital Netz Bern AG, 3007,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Elfgen","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Kantonsspital Winterthur , 8401 Winterthur,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"Bech-Hohenberger","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dow Mu","family":"Koh","sequence":"additional","affiliation":[{"name":"Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research , Sutton SM2 5PT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Gutzeit","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Medicine, University of Lucerne , 6002 Lucerne,","place":["Switzerland"]},{"name":"Department of Radiology and Nuclear Medicine, Kantonsspital Schaffhausen , 8208 Schaffhausen,","place":["Switzerland"]},{"name":"Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich , 8093 Zurich,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2026011615173179700_tqaf215-B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.iac.2021.10.001","article-title":"Anaphylaxis to drugs, biological agents, and vaccines","volume":"42","author":"Shah","year":"2022","journal-title":"Immunol Allergy Clin North 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