{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:34:21Z","timestamp":1772181261083,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1178","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To access the impact of intravenous contrast on the diagnostic efficacy of abdominal spectral CT-based vertebral hydroxyapatite (HAP) concentration measurement for bone mineral density (BMD) assessment in menopausal women, women undergoing menopausal transition, and men older than 50\u2009years with liver cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and seventy-two patients (mean age, 63.78\u2009\u00b1\u20097.20\u2009years; range, 51-82\u2009years) with liver cirrhosis enrolled in the study. These individuals underwent comprehensive abdominal spectral abdominal spectral CT scans, which included both unenhanced and contrast-enhanced arterial phase (AP) and portal venous phase (VP). Vertebral HAP concentration was quantified in the medullary compartment of vertebral body (L1-L3) using HAP-based material decomposition images. The receiver operating characteristic (ROC) curves were adapted to investigate the diagnostic efficacy of using unenhanced, AP and VP HAP concentrations for evaluating BMD validated by T-scores on dual-energy X-ray absorptiometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HAP values were significantly different among the 3 scan phases (all P\u2009&amp;lt;\u2009.05). By adjusting thresholds, high accuracies were obtained for detecting low bone mass (osteoporosis or osteopenia) with HAP measurements in all scan phases (all areas-under-ROC &amp;gt; 0.9). The data did not reveal a statistically significant disparity between the unenhanced and AP (P\u2009=\u2009.055) to detect low bone mass. The efficacies for detecting low bone mass had statistically significant reduction with HAP concentrations in VP (P\u2009=\u2009.012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vertebral HAP concentrations increased in AP and VP compared to unenhanced phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>Adjusting thresholds higher in contrast-enhanced phases may maintain high detection efficacies for low bone mass.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf250","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:54:59Z","timestamp":1760363699000},"page":"276-283","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic ability of spectral CT-based vertebral hydroxyapatite concentration for bone mineral density assessment in patients with liver cirrhosis: evaluating in unenhanced, arterial, and portal venous phase after intravenous contrast administration"],"prefix":"10.1093","volume":"99","author":[{"given":"Xiaoyue","family":"Cheng","sequence":"first","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-713X","authenticated-orcid":false,"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Li","sequence":"additional","affiliation":[{"name":"GE HealthCare China , Beijing 100176,","place":["P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing 100050,","place":["P.R. 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clinical densitometry and executive summary of the 2007 ISCD position development conference","volume":"11","author":"Baim","year":"2008","journal-title":"J Clin Densitom"},{"key":"2026022702513201300_tqaf250-B10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"key":"2026022702513201300_tqaf250-B11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1148\/radiol.2016161797","article-title":"Influence of parathyroidectomy on bone calcium concentration: evaluation with spectral CT in patients with secondary hyperparathyroidism undergoing hemodialysis-A prospective feasibility 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