{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:41:43Z","timestamp":1789933303390,"version":"4.0.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1178","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mesonephric-like adenocarcinoma (MLA) is a newly classified endometrial carcinoma known for its poor prognosis, although the imaging characteristics of this tumour have yet to be reported. This study aims to clarify the imaging characteristics of MLA of the endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Imaging findings of 8 pathologically confirmed cases with MLA were retrospectively analysed. The mean patients were 65\u2009years old (57-72) and were postmenopausal. Contrast-enhanced MR was available in all cases, including dynamic contrast enhancement (DCE) in 7. Pre- and post-contrast CT and FDG-PET\/CT were performed in 6 and 2, respectively. We analysed the size, location, growth pattern, signal intensity on T1-, T2-weighted images, the pattern of enhancement on DCE and static phase, ADC, local extension on MR, density on pre-contrast CT, SUVmax on FDG-PET\/CT, and metastatic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven of the 8 patients had an endophytic, eccentric growth pattern. The tumour location within the uterus, the signal intensity, and the density varied. However, the ADC was low, and SUVmax was high in all available cases. The enhancing pattern of the solid part was transient early in 5 and gradually in 2 of 7 patients with DCE, and a micro-honeycombing pattern was observed on the static phase in 6 of the 8 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although in a limited number of cases in a single-institute analysis, large eccentric masses within the myometrium with restricted diffusion and a micro-honeycombing pattern may be imaging characteristics of MLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This is the first manuscript describing the imaging features of MLA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqaf257","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T20:15:32Z","timestamp":1760559332000},"page":"292-298","source":"Crossref","is-referenced-by-count":1,"title":["Imaging features of mesonephric-like adenocarcinoma of the endometrium"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-0395","authenticated-orcid":false,"given":"Yumiko O","family":"Tanaka","sequence":"first","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Diagnostic Imaging Department, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Department of Pathology, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Tonooka","sequence":"additional","affiliation":[{"name":"Cancer Institute, Japanese Foundation for Cancer Research Division of Pathology, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Ito","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Department of Pathology, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanshiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Department of Gynecologic Oncology, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kitai","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Diagnostic Imaging Department, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kanao","sequence":"additional","affiliation":[{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research Department of Gynecologic Oncology, , Koto-ku, Tokyo, 135-8550,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"2026022702513672100_tqaf257-B1","first-page":"264","volume-title":"WHO Classification of Tumours Editorial Board. 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A study of 49 cases","volume":"14","author":"Ferry","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"2026022702513672100_tqaf257-B3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000478-200103000-00013","article-title":"Mesonephric adenocarcinomas of the uterine cervix: a study of 11 cases with immunohistochemical findings","volume":"25","author":"Silver","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2026022702513672100_tqaf257-B4","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1097\/00000478-200112000-00011","article-title":"Mesonephric adenocarcinoma of the uterine corpus: CD10 expression as evidence of mesonephric differentiation","volume":"25","author":"Ordi","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2026022702513672100_tqaf257-B5","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/his.12895","article-title":"Hormone receptor-negative, thyroid transcription factor 1-positive uterine and ovarian adenocarcinomas: report of a series of mesonephric-like adenocarcinomas","volume":"68","author":"McFarland","year":"2016","journal-title":"Histopathology"},{"key":"2026022702513672100_tqaf257-B6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/PAS.0000000000001401","article-title":"Mesonephric-like carcinoma of the endometrium: a subset of endometrial carcinoma with an aggressive behaviour","volume":"44","author":"Euscher","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"2026022702513672100_tqaf257-B7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/PAS.0000000000001873","article-title":"Mesonephric-like endometrial carcinoma: results from immunohistochemical screening of 300 endometrial carcinomas and carcinosarcomas for this often overlooked and potentially aggressive entity","volume":"46","author":"Mills","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"2026022702513672100_tqaf257-B8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00432-019-03123-7","article-title":"Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma","volume":"146","author":"Horn","year":"2020","journal-title":"J Cancer Res Clin Oncol"},{"key":"2026022702513672100_tqaf257-B9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.21873\/cgp.20338","article-title":"Mesonephric-like adenocarcinoma of the uterine corpus: comprehensive analyses of clinicopathological, molecular, and prognostic characteristics with retrospective review of 237 endometrial carcinoma cases","volume":"19","author":"Kim","year":"2022","journal-title":"Cancer Genomics Proteomics"},{"key":"2026022702513672100_tqaf257-B10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13000-019-0830-4","article-title":"Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a mullerian duct lineage: a case report","volume":"14","author":"Yano","year":"2019","journal-title":"Diagn Pathol"},{"key":"2026022702513672100_tqaf257-B11","first-page":"188","volume-title":"Atlas of Gynecologic Surgical Pathology. 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