{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:32:59Z","timestamp":1777926779018,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1181","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic performance of [68Ga]Ga-FAPI PET\/CT\u2013derived metabolic parameters in thyroid nodules and their association with cytological risk stratification, with particular emphasis on indeterminate nodules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with 53 thyroid nodules who underwent [68Ga]Ga-FAPI PET\/CT were prospectively analysed. Maximum standardized uptake value (SUVmax) and tumour-to-background ratio (TBR) were calculated for each nodule. Ultrasound-based malignancy classification (USG-BM) and Bethesda cytology categories were recorded. Comparisons between benign and malignant nodules were performed in the overall cohort (Bethesda I-VI) and within the Bethesda III-IV subgroup. Multivariable logistic regression was used to identify independent predictors of malignancy. Diagnostic performance was assessed using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the overall cohort, SUVmax and TBR were significantly higher in malignant nodules than in benign nodules (P\u2009&amp;lt;\u2009.01). In multivariable analysis, TBR showed a stronger independent association with malignancy, whereas USG-BM was not independently predictive. Within the Bethesda III-IV subgroup, SUVmax and TBR did not differ significantly in univariable analyses; however, TBR demonstrated a borderline independent association with malignancy in multivariable analysis (P\u2009=\u2009.058). Maximum standardized uptake value and TBR values were significantly higher in Bethesda V-VI nodules compared with Bethesda III-IV nodules (both P\u2009&amp;lt;\u2009.001). Receiver operating characteristic (ROC) analysis demonstrated good discriminative performance for both parameters, with TBR yielding a higher area under the curve and high negative predictive values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>[68Ga]Ga-FAPI PET\/CT\u2013derived metabolic parameters, particularly TBR, show promising diagnostic performance for thyroid nodule characterization. High negative predictive values suggest a potential complementary role for excluding malignancy, especially in indeterminate nodules. Further multicentre studies are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>[68Ga]Ga-FAPI PET\/CT\u2013derived metabolic parameters were higher in malignant thyroid nodules compared with benign lesions. These findings suggest that FAPI PET\/CT may provide complementary functional information in nodules with indeterminate cytology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag042","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:18:28Z","timestamp":1771960708000},"page":"959-966","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of [68Ga]Ga-FAPI PET\/CT\u2013derived parameters in thyroid nodules with emphasis on indeterminate cytology"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3605-7386","authenticated-orcid":false,"given":"Merve","family":"Okuyan","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Recep Tayyip Erdogan University Training and Research Hospital , Rize, 53000,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Elboga","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gaziantep University Medicine Faculty , Gaziantep, 27310,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Bastemir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Sanko University Medicine Faculty , Gaziantep, 27090,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokturk","family":"Maralcan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sanko University Medicine Faculty , Gaziantep, 27090,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seckin","family":"Bilgic","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Uludag University Medicine Faculty , Bursa, 16120,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertan","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gaziantep University Medicine Faculty , Gaziantep, 27310,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Sokucu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanko University Medicine Faculty , Gaziantep, 27090,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"2026050118214142300_tqag042-B1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7326\/0003-4819-69-3-537","article-title":"The significance of nontoxic thyroid nodules","volume":"69","author":"Vander","year":"1968","journal-title":"Ann Intern Med"},{"key":"2026050118214142300_tqag042-B2","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1158\/1055-9965.EPI-21-1440","article-title":"Epidemiology of thyroid cancer","volume":"31","author":"Kitahara","year":"2022","journal-title":"Cancer Epidemiol 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