{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:08:08Z","timestamp":1779451688238,"version":"3.53.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1182","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Comparing risk grouping, target delineation, and dosimetric parameters between RT plans based on conventional imaging (CT and\/or MRI pelvis with bone scan) versus 18F-PSMA PET\/CT in the same patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 75 newly diagnosed PCa patients treated with definitive RT between January 2019 and December 2022 at our center were included. Each underwent standard imaging and 18F-PSMA PET\/CT. Two RT plans were generated; one from conventional imaging and another from PSMA PET\/CT data using IMRT or RapidArc on the Eclipse (Varian, USA) system. Plans were compared regarding target volumes (TVs), dose-volume histograms (DVH), and doses to organs at risk (OARs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age was 69.6\u2009\u00b1\u20098.1\u2009years, and mean pretreatment PSA was 33.47\u2009\u00b1\u200942.05\u2009ng\/mL. Gleason score (GS) was 7 in 50.7% and 8\u201310 in 26.6%. PSMA-PET\/CT altered TVs in 26 patients (34.7%). PSMA-based RT plans showed significantly higher rectal V60% (19.96% vs 18.1%, P\u2009=\u2009.024), femoral maximum dose (46.37\u2009Gy vs 41.98\u2009Gy, P\u2009=\u2009.006), and bowel maximum dose (54.7\u2009Gy vs 46.3\u2009Gy, P\u2009=\u2009.014). Upstaged patients had larger mean prostate volumes (77.53\u2009\u00b1\u200934.76\u2009cc vs 59.76\u2009\u00b1\u200930.6\u2009cc; P\u2009=\u2009.026).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>18F-PSMA-PET\/CT significantly impacts staging and RT planning in prostate cancer, leading to altered TVs and dosimetry, significantly in patients with larger prostates, but non significantly in patients with GS\u2009\u2265\u20098, and higher PSA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>PSMA PET\/CT meaningfully changes staging, TVs, and dosimetry. It highlights the modality\u2019s value in improving accuracy in definitive RT planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag057","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:01:18Z","timestamp":1773212478000},"page":"1125-1130","source":"Crossref","is-referenced-by-count":1,"title":["Impact of PSMA PET\/CT on initial staging and planning of definitive radiation therapy in prostate cancer"],"prefix":"10.1093","volume":"99","author":[{"given":"Rasha","family":"Elsaka","sequence":"first","affiliation":[{"name":"Clinical Oncology and Nuclear Medicine Department, Alexandria University , Alexandria 21526,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-8473","authenticated-orcid":false,"given":"Hanady","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Alexandria University , Alexandria 21526,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Eldrieny","sequence":"additional","affiliation":[{"name":"Radiological Sciences and Medical Imaging Department, Faculty of Applied Health Science Technology, Pharos University , Alexandria 21526,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Kotb","sequence":"additional","affiliation":[{"name":"Faculty of Allied Medical Science, Pharos University , Alexandria 21526,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Morsi","sequence":"additional","affiliation":[{"name":"Radiation Sciences Department, Medical Research Institute, Alexandria University , Alexandria 21526,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Elsaid","sequence":"additional","affiliation":[{"name":"Clinical Oncology and 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