{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:08:04Z","timestamp":1779451684180,"version":"3.53.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1182","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305013"],"award-info":[{"award-number":["82305013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2024-I2M-C&T-B-064"],"award-info":[{"award-number":["2024-I2M-C&T-B-064"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the clinical application of AlignRT surface-guided radiotherapy (SGRT) by quantifying interfractional setup errors in patients with breast-conserving surgery (BCS) stratified by the surgical side and use of thermoplastic immobilization masks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled 125 patients with BCS treated at our center between January 2021 and June 2025. Patients were grouped by the surgical side (left\/right) and immobilization method (with\/without thermoplastic mask). After SGRT setup, cone-beam computed tomography (CBCT) was acquired for each fraction. Systematic and random errors were analyzed and 3-dimensional planning target volume (PTV) margins were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 868 CBCT scans were obtained. With immobilization masks, left-sided patients exhibited significantly different setup errors from right-sided patients in the X (0.04\u2009\u00b1\u20090.25\u2009cm vs. \u22120.05\u2009\u00b1\u20090.30\u2009cm, P\u2009&amp;lt;\u2009.001) and Y (\u22120.09\u2009\u00b1\u20090.26\u2009cm vs.0.02\u2009\u00b1\u20090.30\u2009cm, P\u2009&amp;lt;\u2009.001) directions. Without immobilization masks, differences persisted in X (-0.05\u2009\u00b1\u20090.22\u2009cm vs.0.01\u2009\u00b1\u20090.27\u2009cm, P\u2009=\u2009.017) and Y (0.03\u2009\u00b1\u20090.23\u2009cm vs.0.08\u2009\u00b1\u20090.27\u2009cm, P\u2009=\u2009.039). Irrespective of the side, mask use significantly affected the errors in all 3 directions (all P\u2009&amp;lt;\u2009.05). The required PTV margins (cm) were: left BCS with mask (0.51, 0.51, 0.54), and without mask (0.47, 0.49, 0.57); right BCS with mask (0.64, 0.63, 0.55), and without mask (0.59, 0.62, 0.53).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In SGRT-based workflows for patients with BCS, omitting the thermoplastic mask improves setup reproducibility. Right-sided BCS cases require larger margins than left-sided cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This study provides clinical recommendations for patient positioning and immobilization techniques in whole-breast radiotherapy following breast-conserving surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag058","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:17:58Z","timestamp":1774779478000},"page":"1131-1137","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of patient setup accuracy using optical surface guidance in postoperative radiotherapy for patients with breast cancer after breast-conserving surgery"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6873-2717","authenticated-orcid":false,"given":"Bao","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6095-9999","authenticated-orcid":false,"given":"Jiangtao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7507-2890","authenticated-orcid":false,"given":"Yongtai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8421-4945","authenticated-orcid":false,"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9823-0424","authenticated-orcid":false,"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5891-0939","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2320-6752","authenticated-orcid":false,"given":"Fukui","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-6883","authenticated-orcid":false,"given":"Tantan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 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