{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:53:59Z","timestamp":1781718839069,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1183","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jiangsu Province Capability Improvement Project through Science, Technology and Education","award":["JSDW202243"],"award-info":[{"award-number":["JSDW202243"]}]},{"name":"Medical Research Project of Jiangsu Provincial Health Commission","award":["MQ2024050"],"award-info":[{"award-number":["MQ2024050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the value of synthetic MRI (SyMRI) of extraocular muscles (EOMs) in determining the disease activity of thyroid-associated ophthalmopathy (TAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy-seven patients with TAO (31 active; 46 inactive) were prospectively enrolled. Orbital SyMRI was performed and post-processed to generate quantitative maps (T1 map, T2 map, and proton density [PD] map) and contrast-weighted images (double inversion recovery [DIR], short inversion recovery [STIR], and fluid-attenuated inversion recovery [FLAIR]). Maximum, mean, and minimum values of PD, T1 relaxation time (T1RT), and T2 relaxation time (T2RT) of EOMs, and the signal intensity ratio (SIR) of contrast-weighted images were calculated and compared between 2 groups. Multivariate logistic regression identified independent predictors of disease activity. Receiver operating characteristic curve analyses and DeLong tests evaluated and compared the diagnostic performance of significant parameters and combined models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Active TAO patients had higher values of both quantitative and semi-quantitative parameters than inactive patients, except for FLAIR-Min (all P\u2009&amp;lt;\u2009.05). DIR-Mean, PD-Mean, T1RT-Mean, and T2RT-Mean of EOMs were independently associated with active TAO (all P\u2009&amp;lt;\u2009.05). The combined model integrating 4 independent predictors showed higher diagnostic performance (AUC, 0.884; specificity, 89.13%; sensitivity, 77.42%) than DIR-Mean (AUC\u2009=\u20090.802), PD-Mean (AUC\u2009=\u20090.818), T1RT-Mean (AUC\u2009=\u20090.835), or T2RT-Mean (AUC\u2009=\u20090.824) alone in distinguishing active from inactive patients (all P\u2009&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SyMRI might be one promising imaging modality for determining the disease activity of TAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>SyMRI quantifies PD, T1RT, and T2RT in a single scan with clinically acceptable time. Our study innovatively synthesized multiple contrast-weighted images, improving the efficacy of TAO staging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag082","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:06:56Z","timestamp":1776136016000},"page":"1368-1376","source":"Crossref","is-referenced-by-count":0,"title":["Pilot study using synthetic MRI for determining the disease activity of thyroid-associated ophthalmopathy"],"prefix":"10.1093","volume":"99","author":[{"given":"Ying","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing, 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing, 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing, 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing, 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ting","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing, 210000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated 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