{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:08:39Z","timestamp":1779451719285,"version":"3.53.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1182","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the role of clinical and pathological variables, multiparametric magnetic resonance imaging (mpMRI), and Ga-68-PSMA PET\/CT in prediction upgrading in patients who underwent radical prostatectomy (RP) for clinically insignificant prostate cancer (ciPCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with The International Society of Urological Pathology (ISUP) grade group(GG) 1 by biopsy (bISUP GG 1) who underwent Ga-68-PSMA PET were reviewed. 38 who did not upgrade after RP were defined as group 1, and 37 who were upgraded after RP were defined as group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with bISUP GG 1, the upgrade detection rate of the ISUP GG on RP material was 49.3%. PI-RADS 3, 4, and 5 scores were 71.1%, 18.4%, and 2.6% in group 1, respectively, whereas 51.4%, 18.9%, and 29.7% in group 2, respectively (p\u2009=\u20090.002). Mean index lesion diameter on mpMRI (p\u2009=\u20090.007) were found to be higher in patients who upgraded. The SUVmax detected on Ga-68-PSMA PET\/CT was 4.65 in group 1 and 7 in group 2 (p\u2009=\u20090.003). ROC curve analysis provided a cut-off value of 4.6\u2009g\/mL for the SUVmax that would predict upgrading. PI-RADS 4-5 lesions on mpMRI (OR: 3.354, 95% CI: 1.124\u201310.007, p\u2009=\u20090.030) and SUVmax\u2009\u2265\u20094.6 on PSMA PET\/CT (OR: 6.113, 95%CI: 1.893\u201319.875, p\u2009=\u20090.002) were found to be predictors for upgrading in multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ga-68-PSMA PET\/CT was found to be a potentially useful imaging biomarker for predicting pathological upgrading from combined systematic biopsy and mpMRI- targeted biopsy to RP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>For patients with ciPCa, there is a high likelihood of risk reclassification if they have PI-RADS 4-5 score and SUVmax higher than 4.6 on Ga-68-PSMA PET\/CT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag085","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T04:12:57Z","timestamp":1776571977000},"page":"1162-1170","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of upgrading in clinically insignificant prostate cancer patients undergoing radical prostatectomy: the value of Ga-68-PSMA PET\/CT"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-6790","authenticated-orcid":false,"given":"Mert Hamza","family":"\u00d6zbilen","sequence":"first","affiliation":[{"name":"Department of Urology, Health Sciences University Adana City Training and Research Hospital , Adana,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-4069","authenticated-orcid":false,"given":"Erkin","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Urology, Frimley Health NHS Trust , 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