{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:54:44Z","timestamp":1781718884212,"version":"3.54.5"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1183","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"GE Healthcare Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the incidence and severity of contrast-associated acute kidney injury (CA-AKI), and its predictive factors in trauma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Trauma patients from the Regional Korea Trauma Center who underwent iodixanol-enhanced CT and were monitored for 72\u2009hours post-scan were included. Demographics, comorbidities, and lab results were collected. CA-AKI was defined by the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Severity of CA-AKI was classified by the risk, injury, failure, loss of kidney function, and end-stage renal failure (RIFLE) criteria. Trauma severity was assessed by the injury severity score (ISS) category. Predictive factors of CA-AKI were evaluated by univariate and multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1115 patients undergoing iodixanol-enhanced CT, 799 with complete data were included. Overall CA-AKI incidence was 3.80% (30\/799), and severe renal failure occurred in 2.87% (23\/799). CA-AKI incidence by ISS category was 1.52% (minor), 3.95% (moderate), 42.30% (serious), and 75.0% (severe). Upon univariate analysis, significant predictive factors of CA-AKI included hypertension [odds ratio (OR) 2.87], heart disease (OR 4.06), serious ISS (OR 47.50), and severe ISS (OR 194.33). Upon multivariate analysis, significant predictive factors were ISS serious category (OR 48.20), and ISS severe category (OR 245.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In trauma patients who underwent iodixanol-enhanced CT, incidence of CA-AKI was considerably low at 3.8%, with trauma severity as a significant predictive factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>Iodixanol-enhanced CT demonstrates low CA-AKI incidence and favorable safety in trauma patients. These findings support its clinical utility in high-trauma cases where renal risk is elevated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag099","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:03:28Z","timestamp":1778040208000},"page":"1414-1421","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of contrast-associated acute kidney injury in trauma patients undergoing contrast-enhanced computed tomography using iso-osmolar contrast media"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8355-7847","authenticated-orcid":false,"given":"Hyun Seung","family":"Lee","sequence":"first","affiliation":[{"name":"Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center Department of Radiology, , 164 World cup-ro , Yeongtong-gu, Suwon, 16499,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8832-6165","authenticated-orcid":false,"given":"Jimi","family":"Huh","sequence":"additional","affiliation":[{"name":"Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center Department of Radiology, , 164 World cup-ro , Yeongtong-gu, Suwon, 16499,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-0942","authenticated-orcid":false,"given":"Kyungmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center Department of Radiology, , 164 World cup-ro , Yeongtong-gu, Suwon, 16499,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center Department of Radiology, , 164 World cup-ro , Yeongtong-gu, Suwon, 16499,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-3423","authenticated-orcid":false,"given":"Jayoung","family":"Moon","sequence":"additional","affiliation":[{"name":"Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center Department of Radiology, , 164 World cup-ro , Yeongtong-gu, Suwon, 16499,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"2026061713111555800_tqag099-B1","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1038\/sj.ki.5000368","article-title":"Contrast-induced nephropathy: definition, epidemiology, and patients at risk","volume":"69","author":"Mehran","year":"2006","journal-title":"Kidney Int Suppl"},{"key":"2026061713111555800_tqag099-B2","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3348\/kjr.2014.15.4.456","article-title":"Contrast-induced nephropathy in patients undergoing intravenous contrast-enhanced computed tomography in Korea: a multi-institutional study in 101487 patients","volume":"15","author":"Lee","year":"2014","journal-title":"Korean J Radiol"},{"key":"2026061713111555800_tqag099-B3","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00068-021-01753-6","article-title":"Prevalence and outcome of contrast-induced nephropathy in major trauma patients","volume":"48","author":"Kelemen","year":"2022","journal-title":"Eur J Trauma Emerg Surg"},{"key":"2026061713111555800_tqag099-B4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.20408\/jti.2016.29.4.124","article-title":"The risk factors for developing contrast-induced nephropathy after the evaluation of trauma patients at a regional trauma center in Korea","volume":"29","author":"An","year":"2016","journal-title":"J Trauma Inj"},{"key":"2026061713111555800_tqag099-B5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/MEJ.0b013e328270367d","article-title":"The incidence of contrast-induced nephropathy in trauma patients","volume":"15","author":"Hipp","year":"2008","journal-title":"Eur J Emerg Med"},{"key":"2026061713111555800_tqag099-B6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1056\/NEJMoa021833","article-title":"Nephrotoxic effects in high-risk patients undergoing angiography","volume":"348","author":"Aspelin","year":"2003","journal-title":"N Engl J Med"},{"key":"2026061713111555800_tqag099-B7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ijcard.2014.01.075","article-title":"Nephropathy after administration of iso-osmolar and low-osmolar contrast media: evidence from a network meta-analysis","volume":"172","author":"Biondi-Zoccai","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026061713111555800_tqag099-B8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1159\/000332384","article-title":"Effects of intra-arterial and intravenous iso-osmolar contrast medium (iodixanol) on the risk of contrast-induced acute kidney injury: a meta-analysis","volume":"1","author":"McCullough","year":"2011","journal-title":"Cardiorenal Med"},{"key":"2026061713111555800_tqag099-B9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1097\/00004424-199911000-00004","article-title":"Pathophysiology of radiocontrast nephropathy: a role for medullary hypoxia","volume":"34","author":"Heyman","year":"1999","journal-title":"Invest Radiol"},{"key":"2026061713111555800_tqag099-B10","doi-asserted-by":"publisher","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"2026061713111555800_tqag099-B11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1177\/0885066607299510","article-title":"Defining acute renal failure: the RIFLE criteria","volume":"22","author":"Venkataraman","year":"2007","journal-title":"J Intensive Care Med"},{"key":"2026061713111555800_tqag099-B12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J Trauma Acute Care Surg"},{"key":"2026061713111555800_tqag099-B13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1148\/radiol.2481071484","article-title":"Iso-osmolality versus low-osmolality iodinated contrast medium at intravenous contrast-enhanced CT: effect on kidney function","volume":"248","author":"Nguyen","year":"2008","journal-title":"Radiology"},{"key":"2026061713111555800_tqag099-B14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.injury.2013.07.013","article-title":"The incidence and outcomes of acute kidney injury amongst patients admitted to a level I trauma unit","volume":"45","author":"Skinner","year":"2014","journal-title":"Injury"},{"key":"2026061713111555800_tqag099-B15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12882-015-0026-4","article-title":"Acute kidney injury in an intensive care unit of a general hospital with emergency room specializing in trauma: an observational prospective study","volume":"16","author":"Santos","year":"2015","journal-title":"BMC Nephrol"},{"key":"2026061713111555800_tqag099-B16","doi-asserted-by":"publisher","first-page":"12331","DOI":"10.1038\/s41598-022-16690-6","article-title":"A simple proteinuria-based risk score predicts contrast-associated acute kidney injury after percutaneous coronary intervention","volume":"12","author":"Fujiwara","year":"2022","journal-title":"Sci Rep"},{"key":"2026061713111555800_tqag099-B17","doi-asserted-by":"publisher","first-page":"e0000162","DOI":"10.1371\/journal.pgph.0000162","article-title":"National trauma system establishment based on implementation of regional trauma centers improves outcomes of trauma care: a follow-up observational study in South Korea","volume":"2","author":"Jung","year":"2022","journal-title":"PLOS Glob Public Health"}],"container-title":["British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/advance-article-pdf\/doi\/10.1093\/bjr\/tqag099\/68223911\/tqag099.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/99\/1183\/1414\/68223911\/tqag099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/99\/1183\/1414\/68223911\/tqag099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:11:31Z","timestamp":1781716291000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/99\/1183\/1414\/8670099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":17,"journal-issue":{"issue":"1183","published-online":{"date-parts":[[2026,5,5]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bjr\/tqag099","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,5,5]]}}}