{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:24:00Z","timestamp":1787171040627,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1185","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To retrospectively assess how urine-hyperexcreting procedures influence oncologic and functional long-term outcomes of endophytic renal cell carcinomas (RCCs) treated with percutaneous radiofrequency ablation (RFA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between June 2014 and March 2021, 61 patients underwent CT-guided RFA to treat a histologically proven endophytic RCC. The median RENAL nephrometry score was 10 (7-11). Furosemide was intravenously injected just prior to beginning ablation cycles and normal saline was intravenously infused during RFA procedures. All were followed for 36-109\u2009months (median, 54\u2009months; mean, 58\u2009months). A 5-year local tumor progression (LTP)-free survival rate was calculated with Kaplan-Meier Analysis. Estimated glomerular filtration rates (eGFR) before and after RFA were compared with a paired-t-test. The number of patients with an eGFR decreases to less than 60\u2009mL\/min\/1.73m2 were assessed following RFA. The types or rates of major complication were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 5-year LTP-free survival rate was 96.7% (59\/61). Two patients had LTP, which were treated with additional RFA or surgery. Pre-RFA and post-RFA eGFRs were 86.5\u2009\u00b1\u200918.2\u2009mL\/min\/1.73 m2 and 77.0\u2009\u00b1\u200919.5\u2009mL\/min\/1.73\u2009m2, respectively (P\u2009&amp;lt;\u2009.001). Among 29 patients with eGFR of \u226560 and &amp;lt;90\u2009mL\/min\/1.73\u2009m2, 8 (27.6%) had eGFRs decreased under 60\u2009mL\/min\/1.73\u2009m2; none of the 26 patients with \u226590\u2009mL\/min\/1.73\u2009m2 showed such a decrease. One patient had a major complication (1.6%) which was uretero-pelvic stricture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CT-guided RFA using a urine-hyperexcreting protocol contributes to good oncologic and acceptable functional long-term outcomes of endophytic RCCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>CT-guided RFA using a urine-hyperexcreting protocol has the potential to safely treat endophytic RCCs in patients with normal renal function but needs further investigation to compare diuretic group and non-diuretic or pyeloperfusion group.<\/jats:p>\n                  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