{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:29:01Z","timestamp":1788892141229,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to compare the potential of whole-body silicon photomultiplier positron emission tomography\/computed tomography (WB SiPM PET\/CT) in the prone position with dynamic magnetic resonance imaging (MRI) in determining the extent of breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 77 patients with 84 breast cancers who underwent both PET\/CT and MRI, excluding those who received neoadjuvant chemotherapy. Four tumor thresholds for 18F-fluorodeoxyglucose uptake were defined based on the mean standardized uptake value (SUVmean) and standard deviation (SD) of normal breast tissue: SUVmean+2SD, SUVmean+3SD, 1.5SUVmean+2SD, and 1.5SUVmean+3SD. Semiautomatic measurements of tumor size for each threshold and MRI were compared against pathological tumor size and analyzed by menopausal status and Ki-67 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PET\/CT failed to visualize 2 lesions. No significant differences in the image-to-pathological tumor size ratio were observed between MRI and the 1.5SUVmean+2SD. All MRI and SUV threshold measurements exhibited strong correlations with pathological size. The 1.5SUVmean+2SD demonstrated the highest pathological concordance rate, comparable to MRI. Subgroup analysis revealed that the 1.5SUVmean+2SD was superior for premenopausal patients (60.6%, P\u2009&amp;lt;\u2009.05), while MRI excelled in postmenopausal patients (61.2%). Both 1.5SUVmean+2SD and MRI achieved the highest concordance rates (62.2%) in the high-Ki-67 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 1.5SUVmean+2SD of prone WB SiPM PET\/CT offers a diagnostic performance equivalent to MRI for assessing breast cancer extent, particularly in premenopausal patients, while MRI remains optimal for postmenopausal patients. Both modalities are also highly effective in high Ki-67 tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>These findings highlight the potential of high-resolution semiconductor PET\/CT for assessing breast cancer extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag157","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:16:31Z","timestamp":1782882991000},"source":"Crossref","is-referenced-by-count":1,"title":["Utility of high-resolution semiconductor positron emission tomography\/computed tomography in the assessment of breast cancer extent: comparison with magnetic resonance imaging"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7228-3973","authenticated-orcid":false,"given":"Akina","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Radiology, 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