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PET enables non-invasive imaging of cardiovascular biology at the molecular level, providing insights into pathological processes that precede structural changes detectable by conventional imaging. While conventional PET has been used to investigate isolated cardiac pathologies, its short axial field-of-view (SAFOV) limits the exploration of multi-organ axes influencing cardiovascular disease. The advent of total-body PET systems represents a major advancement in molecular imaging, providing enhanced sensitivities with associated reductions in radiotracer dosing and acquisition times. Furthermore, long axial field-of-view (LAFOV) scanners enable simultaneous assessment of disease activity across the whole cardiovascular and multi-organ systems, facilitating the assessment of organ interactions and network analyses. 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