{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:28:17Z","timestamp":1786321697237,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the dosimetry and robustness of 2 Radixact Synchrony lung stereotactic body radiotherapy (SBRT) tracking strategies: tumor-based lung tracking with respiratory modelling (LwR) and fiducial-based tracking with respiratory modelling (FwR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten stage I non-small-cell lung cancer patients were retrospectively analyzed. SBRT plans (42\u2009Gy in 4 fractions) were generated on maximum-exhalation computed tomography (CT) using planning target volumes (PTVs) created by 3-7\u2009mm isotropic gross tumor volume (GTV) expansion. Each plan was mapped to all 4-dimensional CT (4DCT) phases via isocenter shifts from phase-specific GTV (LwR) or individual fiducial displacement (FwR). Deformable dose accumulation yielded LwR, nearest FwR, and farthest FwR simulated plans. GTV\/PTV V100%, representative organ-at-risk (OAR) doses, and robustness versus target localization error, tumor-fiducial distance, and tumor volume were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a 3-mm PTV margin, FwR showed larger losses in GTV coverage and PTV robustness than LwR (maximum decreases of 9.0% and 26.0%). FwR was less robust, particularly with unfavorable tumor-fiducial geometry. Larger PTV margins progressively mitigated FwR coverage degradation while maintaining acceptable OAR doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For lung SBRT delivered with Radixact Synchrony, LwR was more robust than FwR in this cohort, for which all tumor-fiducial distances exceeded 20\u2009mm. When FwR is required, particularly under suboptimal tumor-fiducial geometry, a 3-mm margin should be used cautiously, and patient-specific evaluation of 5-7\u2009mm margins within OAR dose constraints may be necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>A 4DCT-based simulation using imaging-derived tracking-error scenarios reveals dosimetric robustness differences between LwR and FwR tracking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag170","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:21:53Z","timestamp":1785086513000},"source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric robustness of tumor- and fiducial-based tracking in Radixact lung stereotactic body radiotherapy: a 4-dimensional CT-based simulation using imaging-derived tracking-error scenarios"],"prefix":"10.1093","author":[{"given":"Yugo","family":"Ebinuma","sequence":"first","affiliation":[{"name":"Juntendo University Graduate School of Medicine , Bunkyo-ku, Tokyo 113-8421,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-7921","authenticated-orcid":false,"given":"Tatsuya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Medicine, Juntendo University , Bunkyo-ku, Tokyo 113-8421,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Shirata","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Shonan Kamakura General Hospital , Kamakura City, Kanagawa 247-8533,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-9251","authenticated-orcid":false,"given":"Jun","family":"Takatsu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Medicine, Juntendo University , Bunkyo-ku, Tokyo 113-8421,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-0175","authenticated-orcid":false,"given":"Kotaro","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Medicine, Juntendo University , Bunkyo-ku, Tokyo 113-8421,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, Shonan Kamakura General Hospital , Kamakura City, Kanagawa 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