{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:26:53Z","timestamp":1788791213628,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202217"],"award-info":[{"award-number":["82202217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate coronary inflammation using the perivascular fat attenuation index (FAI) derived from coronary computed tomography angiography (CCTA) in patients with hypertrophic cardiomyopathy (HCM) and to investigate its association with heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 75 patients with HCM and 75 age- and sex-matched controls without structural heart disease. Perivascular FAI was measured around the proximal right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex artery (LCX). All patients underwent cardiac magnetic resonance imaging for comprehensive assessment of left ventricular (LV) morphology, function, and strain parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FAI values were significantly elevated in HCM patients compared to controls across all 3 vessels: LAD-FAI (\u221275.49\u2009\u00b1\u20099.04 vs \u221283.25\u2009\u00b1\u20098.97 HU), LCX-FAI (\u221271.96\u2009\u00b1\u20099.62 vs \u221279.48\u2009\u00b1\u20098.51 HU), and RCA-FAI (\u221277.57\u2009\u00b1\u200910.25 vs \u221283.20\u2009\u00b1\u20098.98 HU); all P\u2009&amp;lt;\u2009.001. LAD-FAI demonstrated modest but significant correlations with markers of adverse LV remodeling, including LV mass index and global strain parameters. On multivariable logistic regression analysis, LAD-FAI was independently associated with HF (OR = 1.40; 95% CI, 1.12-1.99; P\u2009=\u2009.018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Coronary inflammation, quantified by perivascular FAI on CCTA, is significantly heightened in patients with HCM and is correlated with LV hypertrophy and dysfunction. Notably, increased LAD-FAI is independently associated with HF after adjustment for the included CMR parameters, suggesting its potential utility as a noninvasive imaging biomarker for risk stratification in HCM, pending external validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This study provides initial evidence that perivascular FAI, a noninvasive imaging marker of coronary inflammation, is significantly elevated in patients with HCM and correlates with adverse LV remodeling, impaired myocardial strain, and elevated NT-proBNP levels. Notably, increased LAD-FAI was independently associated with HF, suggesting a mechanistic link between regional coronary inflammation and disease severity in HCM. These findings highlight the potential utility of perivascular FAI as an imaging biomarker for HF risk stratification in HCM, warranting further validation in larger, prospective multicenter cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag195","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:50:03Z","timestamp":1787323803000},"source":"Crossref","is-referenced-by-count":0,"title":["Coronary CT angiography-derived perivascular fat attenuation index as a potential marker for heart failure in hypertrophic cardiomyopathy"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-7569","authenticated-orcid":false,"given":"Lin","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, 510080,","place":["P.R. 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Central Laboratory, The Affiliated Shunde Hospital of Jinan University , Foshan, Guangdong Province, 528305,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, 510080,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, 510080,","place":["P.R. 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