{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:06:58Z","timestamp":1790647618623,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0501402"],"award-info":[{"award-number":["2021YFF0501402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471982"],"award-info":[{"award-number":["82471982"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271990"],"award-info":[{"award-number":["82271990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effect of diabetes mellitus on coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis using cardiac CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 409 diabetic patients with stable chest pain who prospectively underwent coronary CT angiography, stress CT myocardial perfusion imaging, and late iodine enhancement. Additionally, 413 symptomatic non-diabetic patients were retrospectively enrolled as controls. Propensity score matching (1:1) was performed based on cardiovascular risk factors. Cardiac CT parameters including coronary artery calcium score, stenosis extent, high-risk plaque features, stress myocardial blood flow (MPF), and myocardial fibrosis were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Diabetic patients exhibited lower global stress MPF (143.1 vs 147.2\u2009mL\/100\u2009mL\/min; P\u2009=\u2009.001) and a higher incidence of myocardial ischemia (43.8% vs 31.3%; P\u2009=\u2009.003). Diabetes remained an independent predictor of ischemia (odds ratio: 2.070; 95% CI, 1.413-3.033; P\u2009&amp;lt;\u2009.001). In CAD-RADS 0 patients, diabetes was associated with higher ischemia rates (33.7% vs 14.5%; P\u2009=\u2009.004), and in CAD-RADS 1-2 patients, with more frequent napkin-ring signs (NRS) (10.3% vs 3.5%; P\u2009=\u2009.042). Coronary calcification and myocardial fibrosis showed no significant difference between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabetes is associated with impaired myocardial perfusion. Even in the absence of coronary atherosclerosis, diabetic patients have a higher prevalence of myocardial ischemia. In patients with nonobstructive CAD, diabetes was associated with a higher frequency of NRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>Diabetes is associated with myocardial perfusion deficits and high-risk plaque independent of other cardiovascular risk determinants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag223","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:28:36Z","timestamp":1789050516000},"source":"Crossref","is-referenced-by-count":0,"title":["Coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis between diabetic and nondiabetic patients with stable chest pain: a propensity score matching study"],"prefix":"10.1093","author":[{"given":"Jiajun","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Radiology, Shanghai General Hospital, Shanghai Jiao 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Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runjianya","family":"Ling","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital , Shanghai 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