{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:06:16Z","timestamp":1790769976350,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the dosimetric performance of HyperArc (HA) and intensity-modulated proton therapy (IMPT) for total scalp irradiation (TSI) in patients with angiosarcoma of the scalp (AS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HyperArc and IMPT treatment plans were retrospectively generated for 27 patients with AS. Prescription doses of 70 and 56\u2009Gy (relative biological effectiveness [RBE]) in 35 fractions were delivered to targets 1 and 2, respectively, using a simultaneous integrated boost technique. HA was optimized to planning target volumes, whereas IMPT employed clinical target volume-based robust optimization. Dose-volume parameters for targets and organs at risk were compared. Beam-on time was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both techniques achieved adequate target coverage within dose constraints; HA demonstrated superior dose homogeneity and conformity for target 1, whereas IMPT exhibited greater dose heterogeneity. IMPT significantly reduced low-dose brain exposure (V5 Gy [RBE]) and high-dose exposure to the optic pathway, eyes, lenses, and hippocampus. HA significantly reduced intermediate-to-high brain exposure (V10-V60 Gy [RBE]), mean brain dose, and parotid dose. Moreover, HA achieved a shorter beam-on time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HyperArc and IMPT offer complementary advantages for TSI in AS. HA improves dose homogeneity, reduces intermediate-to-high brain dose, and enhances treatment efficiency; conversely, IMPT better limits low-dose brain exposure and spares critical neural and ocular structures. Modality selection should be individualized according to patient-specific clinical needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>This study presents a direct dosimetric comparison of HA and IMPT for TSI in angiosarcoma of the scalp, demonstrating complementary strengths that may guide individualized modality selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag224","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:28:36Z","timestamp":1789050516000},"source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric comparison of automated noncoplanar volumetric-modulated arc therapy and intensity-modulated proton therapy for total scalp irradiation in angiosarcoma of the scalp"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-8457","authenticated-orcid":false,"given":"Shoki","family":"Inui","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-0119","authenticated-orcid":false,"given":"Natsuo","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-8923","authenticated-orcid":false,"given":"Taiki","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7151-9094","authenticated-orcid":false,"given":"Yoshihiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Radiological Science, Graduate School of Human Health Science, Tokyo Metropolitan University , Tokyo, 116-8551,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9728-5556","authenticated-orcid":false,"given":"Yuya","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-7707","authenticated-orcid":false,"given":"Sayaka","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567,","place":["Japan"]},{"name":"Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, The University of Osaka , Suita, Osaka, 565-0871,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , Nagoya, 467-8601,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Laboratory of Therapeutic Radiation Biology, Division of Health Science, Graduate School of Medicine, The University of Osaka , Suita, Osaka, 565-0871,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Nishio","sequence":"additional","affiliation":[{"name":"Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, The University of Osaka , Suita, Osaka, 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