{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:46:56Z","timestamp":1791996416211,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate alterations in cerebral blood flow and amplitude of low-frequency fluctuation (CBF-ALFF) spatial coupling in obstructive sleep apnea (OSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-two patients with OSA and 32 healthy controls (HCs) matched for sex, age, and education background were recruited for this work. All participants received arterial spin labeling (ASL) and resting-state functional MRI (rs-fMRI) examinations. Cerebral blood flow and amplitude of low-frequency fluctuation maps were derived from ASL and fMRI data, respectively. Between-group comparisons were performed to identify differences in ALFF, CBF, and CBF-ALFF coupling metrics. Subsequently, correlation analyses were conducted in OSA patients to investigate whether CBF\/ALFF ratios derived from brain regions exhibiting significant group-level differences were associated with polysomnographic and clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with OSA exhibited reduced global spatial CBF-ALFF coupling relative to HCs. Regionally, decreased CBF\/ALFF ratios were primarily observed in the left parahippocampal gyrus, whereas increased ratios were located mainly in the default mode network (DMN), including the left precuneus, right angular gyrus, and left inferior parietal lobule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated disrupted spatial CBF-ALFF coupling in OSA patients. Such coupling alterations reflect broad OSA-associated pathophysiological changes, including but not limited to neurovascular dysfunction, offering new insights into the neuropathological mechanisms of OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>Using combined blood oxygen level-dependent and ASL imaging, this study provides the first characterization of both global and regional CBF-ALFF coupling alterations in OSA, revealing distinct uncoupling signatures in the DMN and medial temporal lobe that deepen our understanding of OSA-related neurovascular pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjr\/tqag229","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:04:41Z","timestamp":1791554681000},"source":"Crossref","is-referenced-by-count":0,"title":["Altered neurovascular coupling in obstructive sleep apnea: assessment via cerebral blood flow and amplitude of low-frequency fluctuation spatial coupling"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7905-2462","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Anhui Medical University , Hefei 230011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second People\u2019s Hospital of Hefei , Hefei 230011,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University , Beijing 100050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Anhui Medical University , Hefei 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