{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:21:40Z","timestamp":1778768500874,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273126"],"award-info":[{"award-number":["82273126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Health Bureau Project","award":["2020CXJQ03"],"award-info":[{"award-number":["2020CXJQ03"]}]},{"name":"State Scholarship Fund of China Scholarship Council","award":["202206235017"],"award-info":[{"award-number":["202206235017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Deep learning neural network (DLNN)-based tools can automate body composition analysis for cancer cachexia research. We aimed to evaluate a DLNN tool trained on a European population of Chinese cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Computed tomography (CT) images at the 3rd lumbar vertebral (L3) level of Chinese gastric cancer patients were retrospectively collected. An externally validated DLNN tool (Mosamatic) was used to segment skeletal muscle, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Manual segmentation was performed using SliceOmatic software (TomoVision, version 5.0). Geometric similarity between automated and manual segmentation, and the reliability was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 203 patients with a median body mass index (BMI) of 22.2\u2009kg\/m2, and 604 CT images at L3 were collected. The median Dice Similarity Coefficient (IQR) of skeletal muscle, VAT and SAT were 0.973 (0.961-0.980), 0.980 (0.964-0.989), and 0.967 (0.945-0.977), respectively. The median Lin\u2019s Concordance Correlation Coefficient for skeletal muscle area (0.983), VAT area (1.000), SAT area (0.998), skeletal muscle radiation attenuation (0.995), VAT radiation attenuation (0.994), and SAT radiation attenuation (0.997) demonstrated excellent reliability. Low BMI (&amp;lt;18.5\u2009kg\/m2) and ascites impaired the agreement between the 2 methods. The automated method showed high diagnostic concordance with manual segmentation for sarcopenia (\u03ba\u2009=\u20090.843, P\u2009&amp;lt;\u2009.001) and myosteatosis (\u03ba\u2009=\u20090.946, P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Mosamatic tool displays excellent generalizability to analyse body compositions in Chinese gastric cancer patients and can facilitate cachexia research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge<\/jats:title>\n                    <jats:p>The Mosamatic tool displayed excellent generalizability without recalibration to analyse body composition on the 3rd lumbar vertebral CT images in Chinese gastric cancer patients.<\/jats:p>\n                  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