{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:44:40Z","timestamp":1753875880423,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":51,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The radiologically isolated syndrome is defined by the presence of incidentally identified T2-weighted hyperintense lesions, highly suggestive of central nervous system demyelination, following an MRI study that is performed for reasons other than for the investigation of symptoms related to multiple sclerosis (MS). These individuals also have no evidence of prior neurological symptoms associated with inflammatory demyelination and no alternative explanation for the observed MRI findings. Recently, the introduction of novel imaging techniques such as the \u201ccentral vein sign\u201d has improved lesion specificity for MS. In addition, the observation of T2-fluid attenuated inversion recovery (FLAIR) mismatch characteristics associated with gliomas and in those with MS with a higher disease burden appear to provide morphological data that relate to disease severity. The value of T2-FLAIR mismatch characteristics in discrete multi-focal lesions has not yet been well defined. Here, we present the value of a fat-suppressed T2-FLAIR sequence in the identification and characterization of T2-weighted hyperintensities resulting from inflammatory demyelination.<\/jats:p>","DOI":"10.1093\/bjrcr\/uaae028","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:23:59Z","timestamp":1724282639000},"source":"Crossref","is-referenced-by-count":0,"title":["T2-fluid attenuated inversion recovery fat-suppressed mismatch in the identification and characterization of lesions related to radiologically isolated syndrome"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-1523","authenticated-orcid":false,"given":"Darin T","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of Neurology, Neuroinnovation Program, Multiple Sclerosis & Neuroimmunology Imaging Program, The University of Texas Southwestern Medical Center , Dallas, TX, 75390-8806, United States"},{"name":"The University of Texas Southwestern Medical Center, Peter O\u2019Donnell Jr. Brain Institute , Dallas, TX, 75390, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-2416","authenticated-orcid":false,"given":"Christine","family":"Lebrun-Frenay","sequence":"additional","affiliation":[{"name":"Neurology, Universit\u00e9 Nice Cote d\u2019Azur, UR2CA-URRIS CRCSEP CHU Nice Pasteur , Nice, 06002, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"issue":"11","key":"2024082420205913300_uaae028-B1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S1474-4422(23)00281-8","article-title":"Radiologically isolated syndrome","volume":"22","author":"Lebrun-Frenay","year":"2023","journal-title":"Lancet 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