{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T10:32:22Z","timestamp":1782556342955,"version":"3.54.5"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>An accurate morphological classification of distinct pulmonary phenotypes in sarcoidosis is lacking. Recently, a multinational Delphi study was conducted to reach a consensus on recognizable high-resolution computer tomography (HRCT) phenotypes in pulmonary sarcoidosis as a basis for a more distinctive classification. The reliability of these phenotypes has not yet been evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>HRCT scans of adult sarcoidosis patients from the pulmonology department of a single sarcoidosis referral center were scored by three blinded independent readers. Seven phenotypes were distinguished as described in the Delphi study. They were divided into two subgroups: \u201cnon-fibrotic\u201d and \u201clikely-to-be fibrotic\u201d. Intra- and inter-reader reliability for scoring the predominant phenotype and the subgroup was assessed using weighted Kappa (Kw) statistics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-five patients (mean age, 47\u2009years \u00b1 12, 28 men) were included. For the scoring of the predominant phenotype, inter-reader reliability between all readers was substantial with an overall Fleiss\u2019 kappa of 0.69 (CI 0.622-0.765, P\u2009&amp;lt;\u2009.001). We observed a substantial inter-reader reliability between readers A and B (Kw of 0.76), between readers B and C (Kw of 0.66) and between readers A and C (Kw of 0.66). For the scoring of the subgroups \u201cnon-fibrotic\u201d vs. \u201clikely-to-be fibrotic,\u201d overall Fleiss\u2019 Kappa was substantial (K\u2009=\u20090.78, CI 0.607-0.944, P\u2009&amp;lt;\u2009.001). We observed a Kw score of 0.76 between readers A and B; 0.81 between readers A and C; 0.76 between readers B and C. Intra-reader reliability was substantial between the scores of A in scoring the predominant phenotypes (Kw of 0.71) and it was almost perfect in scoring the subgroups (Kw of 0.95). Intra-reader reliability was substantial between the scores of B in scoring the predominant phenotype (Kw of 0.66) and subgroups (Kw of 0.72).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The inter- and intra-reader reliability of the newly proposed HRCT phenotypes obtained from the Delphi study is very acceptable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>This study is the first to assess the reliability of these HRCT phenotypes and supports the use of them for classification purposes in future clinical and pathogenetic studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjro\/tzaf017","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:47:45Z","timestamp":1750906065000},"source":"Crossref","is-referenced-by-count":3,"title":["Radiological phenotypes in pulmonary sarcoidosis: a reliability study of newly defined high-resolution computer tomography phenotypes"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0478-1464","authenticated-orcid":false,"given":"Julie","family":"Van Woensel","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasenko","family":"Krdzalic","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"de Jaegere","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlou T H F","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-9087","authenticated-orcid":false,"given":"Sofia","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]},{"name":"Department of Rheumatology, Leiden University Medical Centre , Leiden, Zuid-Holland, 2311EZ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-3091","authenticated-orcid":false,"given":"C\u00e9sar","family":"Magro Checa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-6620","authenticated-orcid":false,"given":"Robert B M","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]},{"name":"Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology Centre, Amsterdam, Noord-Holland, AMC 1105AZ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-2855","authenticated-orcid":false,"given":"R\u00e9my L M","family":"Mostard","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Zuyderland Medical Centre , Heerlen, Limburg, 6419PC,","place":["The Netherlands"]},{"name":"Department of Respiratory Medicine, Maastricht Universal Medical Centre , Maastricht, Limburg, 6229HX,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2025071211564317900_tzaf017-B1","first-page":"736","article-title":"Hunninghake GW, Costabel U, Ando M, et al. 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