{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:01:25Z","timestamp":1787900485190,"version":"build-2784847793"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is no consensus regarding the role of mechanical bowel preparation (MBP) and oral antibiotic prophylaxis (OABP) in reducing postoperative complications in colorectal surgery. The aim of this study was to examine the effect of OABP given in addition to MBP in the setting of a prospective randomized trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients awaiting elective colorectal surgery in four Hungarian colorectal centres were included in this multicentre, prospective, randomized, assessor-blinded study. Patients were randomized to receive MBP with or without OABP (OABP+ and OABP\u2013 groups respectively). The primary endpoints were surgical-site infection (SSI) and postoperative ileus. Secondary endpoints were anastomotic leak, mortality, and hospital readmission within 30 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 839 patients assessed for eligibility between November 2016 and June 2018, 600 were randomized and 529 were analysed. Trial participation was discontinued owing to adverse events in seven patients in the OABP+ group (2.3 per cent). SSI occurred in eight patients (3.2 per cent) in the OABP+ and 27 (9.8 per cent) in the OABP\u2013 group (P\u2009=\u20090.001). The incidence of postoperative ileus did not differ between groups. Anastomotic leakage occurred in four patients (1.6 per cent) in the OABP+ and 13 (4.7 per cent) in the OABP\u2013 (P\u2009=\u20090.02) group. There were no differences in hospital readmission (12 (4.7 per cent) versus 10 (3.6 per cent); P\u2009=\u20090.25) or mortality (3 (1.2 per cent) versus 4 (1.4 per cent); P\u2009=\u20090.39).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OABP given with MBP reduced the rate of SSI and AL after colorectal surgery with anastomosis, therefore routine use of OABP is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjs\/znaa131","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:12:50Z","timestamp":1609456370000},"page":"271-276","source":"Crossref","is-referenced-by-count":37,"title":["Systemic\n                    <i>versus<\/i>\n                    Oral and Systemic Antibiotic Prophylaxis (SOAP) study in colorectal surgery: prospective randomized multicentre trial"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-114X","authenticated-orcid":false,"given":"G","family":"Papp","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical Oncology, Uzsoki Hospital , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy","family":"Saftics","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology, Uzsoki Hospital , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B E","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology, Uzsoki Hospital , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Baracs","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of P\u00e9cs Clinical Centre , P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Vereczkei","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of P\u00e9cs Clinical Centre , P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Koll\u00e1r","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Petz Alad\u00e1r Teaching Hospital , Gy\u0151r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Petz Alad\u00e1r Teaching Hospital , Gy\u0151r, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, National Institute of Oncology, Centre of Oncosurgery , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs","family":"Dub\u00f3czki","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery, National Institute of Oncology, Centre of Oncosurgery , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bursics","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology, Uzsoki Hospital , Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"2023063010501040300_znaa131-B1","doi-asserted-by":"crossref","first-page":"O402","DOI":"10.1111\/codi.13905","article-title":"A European survey of bowel preparation in colorectal surgery","volume":"19","author":"Devane","year":"2017","journal-title":"Colorectal Dis"},{"key":"2023063010501040300_znaa131-B2","volume-title":"Cochrane Database Syst Rev"},{"key":"2023063010501040300_znaa131-B3","first-page":"CD001544","article-title":"Mechanical bowel preparation for elective colorectal surgery","volume":"9","author":"G\u00fcenaga","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"2023063010501040300_znaa131-B4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","article-title":"Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS\u00ae) Society recommendations: 2018","volume":"43","author":"Gustafsson","year":"2019","journal-title":"World J Surg"},{"key":"2023063010501040300_znaa131-B5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00000658-197208000-00019","article-title":"Efficacy of preoperative antimicrobial preparation of the bowel","volume":"176","author":"Nichols","year":"1972","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B6","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/SLA.0000000000001576","article-title":"Benefits of bowel preparation beyond surgical site infection","volume":"264","author":"Althumairi","year":"2016","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jamcollsurg.2015.02.008","article-title":"Nationwide analysis of outcomes of bowel preparation in colon surgery","volume":"220","author":"Moghadamyeghaneh","year":"2015","journal-title":"J Am Coll Surg"},{"key":"2023063010501040300_znaa131-B8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.suc.2018.07.010","article-title":"Enhanced recovery after surgery: recent developments in colorectal surgery","volume":"98","author":"Tiernan","year":"2018","journal-title":"Surg Clin North Am"},{"key":"2023063010501040300_znaa131-B9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/DCR.0000000000001238","article-title":"The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Use of Bowel Preparation in Elective Colon and Rectal Surgery","volume":"62","author":"Migaly","journal-title":"Dis Colon Rectum"},{"key":"2023063010501040300_znaa131-B10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13741-017-0059-2","article-title":"American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on prevention of postoperative infection within an enhanced recovery pathway for elective colorectal surgery","volume":"6","author":"Holubar","year":"2017","journal-title":"Perioper Med"},{"key":"2023063010501040300_znaa131-B11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/SLA.0000000000001041","article-title":"Combined mechanical and oral antibiotic bowel preparation reduces incisional surgical site infection and anastomotic leak rates after elective colorectal resection: an analysis of colectomy-targeted ACS NSQIP","volume":"262","author":"Scarborough","year":"2015","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B12","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/SLA.0000000000001125","article-title":"Oral antibiotic bowel preparation significantly reduces surgical site infection rates and readmission rates in elective colorectal surgery","volume":"261","author":"Morris","year":"2015","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/SLA.0000000000001416","article-title":"Combined preoperative mechanical bowel preparation with oral antibiotics significantly reduces surgical site infection, anastomotic leak, and ileus after colorectal surgery","volume":"262","author":"Kiran","year":"2015","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B14","doi-asserted-by":"crossref","first-page":"O1","DOI":"10.1111\/codi.13534","article-title":"A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery","volume":"19","author":"Vallance","year":"2017","journal-title":"Colorectal Dis"},{"key":"2023063010501040300_znaa131-B15","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s11605-016-3255-3","article-title":"Emerging trends in the etiology, prevention, and treatment of gastrointestinal anastomotic leakage","volume":"20","author":"Chadi","year":"2016","journal-title":"J Gastrointest Surg"},{"key":"2023063010501040300_znaa131-B16","doi-asserted-by":"crossref","first-page":"e183226","DOI":"10.1001\/jamanetworkopen.2018.3226","article-title":"Association of mechanical bowel preparation and oral antibiotics before elective colorectal surgery with surgical site infection: a network meta-analysis","volume":"1","author":"Toh","year":"2018","journal-title":"JAMA Netw Open"},{"key":"2023063010501040300_znaa131-B17","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/bjs.9254","article-title":"Systematic review of perioperative selective decontamination of the digestive tract in elective gastrointestinal surgery","volume":"100","author":"Roos","year":"2013","journal-title":"Br J Surg"},{"key":"2023063010501040300_znaa131-B18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/SLA.0000000000003145","article-title":"The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis","volume":"270","author":"Rollins","year":"2019","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/DCR.0000000000000524","article-title":"Comparing mechanical bowel preparation with both oral and systemic antibiotics versus mechanical bowel preparation and systemic antibiotics alone for the prevention of surgical site infection after elective colorectal surgery: a meta-analysis of randomized controlled clinical trials","volume":"59","author":"Chen","year":"2016","journal-title":"Dis Colon Rectum"},{"key":"2023063010501040300_znaa131-B20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13756-017-0198-8","article-title":"Risk factors and outcomes of organ-space surgical site infections after elective colon and rectal surgery","volume":"6","author":"Gomila","year":"2017","journal-title":"Antimicrob Resist Infect Control"},{"key":"2023063010501040300_znaa131-B21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00423-016-1513-1","article-title":"Preoperative oral antibiotics reduce infections after colorectal cancer surgery","volume":"401","author":"Mik","year":"2016","journal-title":"Langenbecks Arch Surg"},{"key":"2023063010501040300_znaa131-B22","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1097\/DCR.0000000000001108","article-title":"Oral antibiotics as adjunct to systemic antibiotics and mechanical bowel preparation for prevention of surgical site infections in colorectal surgery. Do we really need more trials?","volume":"61","author":"Battersby","year":"2018","journal-title":"Dis Colon Rectum"},{"key":"2023063010501040300_znaa131-B23","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00384-004-0736-8","article-title":"Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics?","volume":"20","author":"Espin-Basany","year":"2005","journal-title":"Int J Colorectal Dis"},{"key":"2023063010501040300_znaa131-B24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00595-006-3410-7","article-title":"Randomized clinical trial comparing intravenous antimicrobial prophylaxis alone with oral and intravenous antimicrobial prophylaxis for the prevention of a surgical site infection in colorectal cancer surgery","volume":"37","author":"Kobayashi","year":"2007","journal-title":"Surg Today"},{"key":"2023063010501040300_znaa131-B25","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/bjs.10281","article-title":"Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection","volume":"103","author":"Ikeda","year":"2016","journal-title":"Br J Surg"},{"key":"2023063010501040300_znaa131-B26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SLA.0000000000002567","article-title":"Efficacy of preoperative oral antibiotic prophylaxis for the prevention of surgical site infections in patients with Crohn disease","volume":"269","author":"Uchino","year":"2019","journal-title":"Ann Surg"},{"key":"2023063010501040300_znaa131-B27","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00384-016-2643-1","article-title":"Differences in surgical site infection between laparoscopic colon and rectal surgeries: sub-analysis of a multicenter randomized controlled trial (Japan-Multinational Trial Organization PREV 07-01)","volume":"31","author":"Goto","year":"2016","journal-title":"Int J Colorectal Dis"},{"key":"2023063010501040300_znaa131-B28","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/DCR.0000000000000927","article-title":"A randomized control trial of preoperative oral antibiotics as adjunct therapy to systemic antibiotics for preventing surgical site infection in clean contaminated, contaminated, and dirty type of colorectal surgeries","volume":"60","author":"Anjum","year":"2017","journal-title":"Dis Colon Rectum"},{"key":"2023063010501040300_znaa131-B29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/bjs5.68","article-title":"Meta-analysis of oral antibiotics, in combination with preoperative intravenous antibiotics and mechanical bowel preparation the day before surgery, compared with intravenous antibiotics and mechanical bowel preparation alone to reduce surgical-site infections in elective colorectal surgery","volume":"2","author":"McSorley","year":"2018","journal-title":"BJS Open"},{"key":"2023063010501040300_znaa131-B30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/codi.14362","article-title":"Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit","volume":"20","author":"Glasbey","year":"2018","journal-title":"Colorectal Dis"},{"key":"2023063010501040300_znaa131-B31","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(19)31269-3","article-title":"Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial","volume":"394","author":"Koskenvuo","journal-title":"Lancet (London, England)"},{"key":"2023063010501040300_znaa131-B32"},{"key":"2023063010501040300_znaa131-B33"},{"key":"2023063010501040300_znaa131-B34","first-page":"784","article-title":"Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017","volume-title":"JAMA Surg","author":"Berr\u00edos-Torres","year":"2017"},{"key":"2023063010501040300_znaa131-B35","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","article-title":"The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research","volume":"69","author":"Lai","year":"2009","journal-title":"Gastrointest Endosc"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/108\/3\/271\/50745228\/znaa131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/108\/3\/271\/50745228\/znaa131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T06:54:59Z","timestamp":1688108099000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/108\/3\/271\/6143806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,2,18]]},"published-print":{"date-parts":[[2021,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znaa131","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2021,2,18]]}}}