{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:15:18Z","timestamp":1787008518309,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ladybird Foundation"},{"DOI":"10.13039\/501100000961","name":"State Health Research Advisory Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001170","name":"Cancer Council of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Royal Perth Hospital Research Foundation"},{"name":"The St John of God Foundation"},{"name":"The Ladybird Foundation"},{"name":"Southern Trust"},{"name":"Grassroots Trust"},{"DOI":"10.13039\/501100001523","name":"Lion Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001523","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Waikato Breast Cancer Research Trust"},{"name":"Western Australian Health Translation Network Early Career Fellowship"},{"name":"Australian Government\u2019s Medical Research Future Fund"},{"name":"Rapid Applied Research Translation program"},{"name":"National Breast Cancer Foundation Investigator Initiated Research Scheme","award":["IIRS-20-011"],"award-info":[{"award-number":["IIRS-20-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim was to determine the cost-effectiveness of radioguided occult lesion localization using 125I-labelled seeds (125I seeds) versus hookwire localization in terms of incremental cost per reoperation avoided for women with non-palpable breast cancer undergoing breast-conserving surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was based on a multicentre RCT with eight study sites comprising seven public hospitals and one private hospital. An Australian public health system perspective was taken. The primary effectiveness outcome for this study was reoperations avoided. Cost-effectiveness was expressed as an incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses were used to explore uncertainty. The willingness to pay (additional cost of localization using 125I seeds justified by reoperation cost avoided) was set at the weighted, top-down cost of reoperation. Costs were in 2019 Australian dollars ($1 was equivalent to \u20ac0.62).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The reoperation rate was 13.9 (95 per cent confidence interval 10.7 to 18.0) per cent for the 125I seed group and 18.9 (14.8 to 23.8) per cent for the hookwire localization group. The ICER for 125I seed versus hookwire localization was $4474 per reoperation averted. The results were most sensitive to uncertainty around the probability of reoperation. Accounting for transition probability and cost uncertainty for 125I seed localization, there was a 77 per cent probability that using 125I seeds would be cost-effective, with a willingness to pay of $7693 per reoperation averted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radioguided occult lesion localization using 125I seeds is likely to be cost-effective, because the marginal (additional) cost compared with hookwire localization is less than the cost of reoperations avoided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bjs\/znaa160","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:12:50Z","timestamp":1609456370000},"page":"843-850","source":"Crossref","is-referenced-by-count":15,"title":["Cost-effectiveness of radioguided occult lesion localization using 125I seeds\n                    <i>versus<\/i>\n             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Western Australia , Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Saunders","sequence":"additional","affiliation":[{"name":"Division of Surgery, School of Medicine, University of Western Australia , Crawley, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Marinovich","sequence":"additional","affiliation":[{"name":"Health Economics and Data Analytics, School of Public Health, Faculty of Health Sciences, Curtin University , Bentley, Western Australia, Australia"},{"name":"Division of Surgery, School of Medicine, University of Western Australia , Crawley, Western Australia, Australia"},{"name":"Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney , Camperdown, New South Wales, 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