{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:15:58Z","timestamp":1792793758540,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Society for Medical Oncology Clinical Research Fellowship to support this study","id":[{"id":"https:\/\/ror.org\/03xtz2n86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute for Health Research (NIHR) Academic Clinical Lectureship and acknowledges support from the NIHR Imperial Biomedical Research Centre","id":[{"id":"https:\/\/ror.org\/01kmhx639","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIHR London In Vitro Diagnostics (IVD) Co-operative and the Morgagni Charity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Data on the long-term symptom burden in patients surviving oesophageal cancer surgery are scarce. The aim of this study was to identify the most prevalent symptoms and their interactions with health-related quality of life.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a cross-sectional cohort study of patients who underwent oesophageal cancer surgery in 20 European centres between 2010 and 2016. Patients had to be disease-free for at least 1 year. They were asked to complete a 28-symptom questionnaire at a single time point, at least 1 year after surgery. Principal component analysis was used to assess for clustering and association of symptoms. Risk factors associated with the development of severe symptoms were identified by multivariable logistic regression models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 1081 invited patients, 876 (81.0 per cent) responded. Symptoms in the preceding 6 months associated with previous surgery were experienced by 586 patients (66.9 per cent). The most common severe symptoms included reduced energy or activity tolerance (30.7 per cent), feeling of early fullness after eating (30.0 per cent), tiredness (28.7 per cent), and heartburn\/acid or bile regurgitation (19.6 per cent). Clustering analysis showed that symptoms clustered into six domains: lethargy, musculoskeletal pain, dumping, lower gastrointestinal symptoms, regurgitation\/reflux, and swallowing\/conduit problems; the latter two were the most closely associated. Surgical approach, neoadjuvant therapy, patient age, and sex were factors associated with severe symptoms.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A long-term symptom burden is common after oesophageal cancer surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bjs\/znab124","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T15:18:31Z","timestamp":1617635911000},"page":"1090-1096","source":"Crossref","is-referenced-by-count":19,"title":["Patient-reported outcomes after oesophagectomy in the multicentre LASER study"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-2017","authenticated-orcid":false,"given":"S R","family":"Markar","sequence":"first","affiliation":[{"name":"Department Surgery and Cancer, Imperial College London , London, UK"},{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet , Stockholm, Sweden"},{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-8402","authenticated-orcid":false,"given":"V","family":"Sounderajah","sequence":"additional","affiliation":[{"name":"Department Surgery and Cancer, Imperial College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Johar","sequence":"additional","affiliation":[{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet , Stockholm, Sweden"},{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-9491","authenticated-orcid":false,"given":"G","family":"Zaninotto","sequence":"additional","affiliation":[{"name":"Department Surgery and Cancer, Imperial College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Castoro","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology of the Oesophagus and Digestive Tract, Veneto Institute of Oncology , Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-0233","authenticated-orcid":false,"given":"P","family":"Lagergren","sequence":"additional","affiliation":[{"name":"Department Surgery and Cancer, Imperial College London , London, UK"},{"name":"Division of Surgery, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet , Stockholm, Sweden"},{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-0386","authenticated-orcid":false,"given":"J A","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Surgery, Trinity Centre for Health Sciences, St James\u2019s Hospital and Trinity College Dublin , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Gisbertz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, location AMC, University of Amsterdam , Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mariette","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncological Surgery, University of Lille, Claude Huriez University Hospital , F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology of the Oesophagus and Digestive Tract, Veneto Institute of Oncology , Padua, 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of Surgery, Trinity Centre for Health Sciences, St James\u2019s Hospital and Trinity College Dublin , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Trinity Centre for Health Sciences, St James\u2019s Hospital and Trinity College Dublin , Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Piessen","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncological Surgery, University of Lille, Claude Huriez University Hospital , F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-9143","authenticated-orcid":false,"given":"H","family":"Brenkman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Centre Utrecht , Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ruurda","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Centre Utrecht , Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"van Hillegersberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Medical Centre Utrecht , Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Lagarde","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC, University Medical Centre , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B P","family":"Wijnhoven","sequence":"additional","affiliation":[{"name":"Department of Surgery, Erasmus MC, University Medical Centre , Rotterdam, the 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Findlay","sequence":"additional","affiliation":[{"name":"Oesophago-gastric Centre, Churchill Hospital, University of Oxford , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Antonowicz","sequence":"additional","affiliation":[{"name":"Oesophago-gastric Centre, Churchill Hospital, University of Oxford , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Maynard","sequence":"additional","affiliation":[{"name":"Oesophago-gastric Centre, Churchill Hospital, University of Oxford , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"McCormack","sequence":"additional","affiliation":[{"name":"Department of Oesophago-Gastric Surgery, Royal Marsden Hospital , London, 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