{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:16:28Z","timestamp":1780413388753,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is a transition from wire-guided localization (WGL) of non-palpable breast cancer to other localization techniques. Multiple prospective studies have sought to establish superior clinical outcomes for radioactive-seed localization (RSL), but consistent and congruent evidence is missing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, female patients with breast cancer operated with breast-conserving surgery after tumour localization of a non-palpable breast cancer or ductal carcinoma in situ (DCIS) were included. The cohort was identified from the nationwide Netherlands Breast Cancer Audit conducted between 2013 and 2018. Trends in localization techniques were analysed. Univariable and multivariable analyses were performed to assess the association between the localization technique and the probability of a reoperation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 28 370 patients were included in the study cohort. The use of RSL increased from 15.7 to 61.1 per cent during the study years, while WGL decreased from 75.4 to 31.6 per cent. The localization technique used (RSL versus WGL) was not significantly associated with the odds of a reoperation, regardless of whether the lesion was DCIS (odds ratio 0.96 (95 per cent c.i. 0.89 to 1.03; P = 0.281)) or invasive breast cancer (OR 1.02 (95 per cent c.i. 0.96 to 1.10; P = 0.518)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RSL is rapidly replacing WGL as the preoperative localization technique in breast surgery. This large nationwide registry study found no association between the type of localization technique and the odds of having a reoperation, thus confirming the results of previous prospective cohort studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znab339","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:33:31Z","timestamp":1631100811000},"page":"53-60","source":"Crossref","is-referenced-by-count":24,"title":["Nationwide registry study on trends in localization techniques and reoperation rates in non-palpable ductal carcinoma <i>in situ<\/i> and invasive breast cancer"],"prefix":"10.1093","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-9999","authenticated-orcid":false,"given":"Bram","family":"Schermers","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute , Amsterdam, The Netherlands"},{"name":"University of Twente, Faculty TNW , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne E","family":"van Riet","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven, The Netherlands"},{"name":"Department of Radiology, Netherlands Cancer Institute , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jeanne","family":"Vrancken Peeters","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-2720","authenticated-orcid":false,"given":"Adri C","family":"Voogd","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Netherlands Comprehensive Cancer Organization , Utrecht, The Netherlands"},{"name":"Department of Epidemiology, Maastricht University , Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-5513","authenticated-orcid":false,"given":"Grard A P","family":"Nieuwenhuijzen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Catharina Hospital , Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennie","family":"ten Haken","sequence":"additional","affiliation":[{"name":"Magnetic Detection & Imaging Group, University of Twente , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J M","family":"Ruers","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Netherlands Cancer Institute , 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