{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:11:59Z","timestamp":1790413919273,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Hull York Medical School, UK"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lower limb amputation (LLA) is typically described as \u2018clean surgery\u2019, but surgical-site infection (SSI) rates are high and there is significant variation in antibiotic prophylaxis practice. This study aimed to determine whether an extended period of antibiotic prophylaxis (5-day course) is superior to a short course (24 h) in preventing SSI in patients undergoing minor and major LLA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients undergoing minor and major amputation from a single vascular unit were recruited and randomized to receive either a 5-day or a 24-h prophylactic course of antibiotics. Patients with significant baseline infection were excluded. Outcomes included the incidence of SSI and impaired wound healing (IWH), both measured using ASEPSIS criteria, the need for further surgery, duration of hospital stay, and mortality up to 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 161 patients were recruited to the study, and 152 were included in the analysis. A 5-day course of antibiotics was associated with a lower incidence of SSI (11.8 versus 39.5 per cent; P &amp;lt; 0.001) and lower incidence of IWH (22.4 versus 58 per cent; P &amp;lt; 0.001). Fewer patients receiving the 5-day course required amputation revisional surgery (6.6 versus 21 per cent; P = 0.010). Duration of hospital stay and mortality rates were similar. The presence of SSI (odds ratio (OR) 5.14, 95 per cent c.i. 1.96 to 13.45; P &amp;lt; 0.001) and IWH (OR 4.62, 1.68 to 12.72; P = 0.003) increased the need for revisional surgery. SSI increased the duration of hospital stay: median 28 (i.q.r. 16\u201340) versus 14 (9\u201321) days (P = 0.045).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SSI and IWH are common after LLA and have a significant impact on outcome. A 5-day course of antibiotic prophylaxis was associated with a reduction in both SSI and IWH compared with a 24-h course, and this reduced the need for further surgery. Registration number: NCT02018094 (http:\/\/www.clinicaltrials.gov); EudraCT 2012-003146-32 (https:\/\/www.clinicaltrialsregister.eu).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znac053","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:13:56Z","timestamp":1643314436000},"page":"426-432","source":"Crossref","is-referenced-by-count":13,"title":["Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial"],"prefix":"10.1093","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-2955","authenticated-orcid":false,"given":"Panayiotis","family":"Souroullas","sequence":"first","affiliation":[{"name":"Hull York Medical School, Hull , UK"},{"name":"Hull University Teaching Hospitals NHS Trust, Hull , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Barnes","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Royal Cornwall Hospital NHS Trust , Truro, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-3925","authenticated-orcid":false,"given":"Daniel","family":"Carradice","sequence":"additional","affiliation":[{"name":"Hull York Medical School, Hull , UK"},{"name":"Hull University Teaching Hospitals NHS Trust, Hull , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Smith","sequence":"additional","affiliation":[{"name":"Hull York Medical School, Hull , UK"},{"name":"Hull University Teaching Hospitals NHS Trust, Hull , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Hull York Medical School, Hull , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Chetter","sequence":"additional","affiliation":[{"name":"Hull York Medical School, Hull , UK"},{"name":"Hull University Teaching Hospitals NHS Trust, Hull , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"2023063011203291300_znac053-B1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.apmr.2004.06.072","article-title":"Reamputation, mortality, and health care costs among persons with dysvascular lower-limb amputations","volume":"86","author":"Dillingham","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"2023063011203291300_znac053-B2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jhin.2004.10.019","article-title":"Adverse impact of surgical site infections in English hospitals","volume":"60","author":"Coello","year":"2005","journal-title":"J Hosp Infect"},{"key":"2023063011203291300_znac053-B3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/jhin.2000.0881","article-title":"The rate and cost of hospital-acquired infections occurring in patients admitted to selected specialties of a district general hospital in England and the national burden imposed","volume":"47","author":"Plowman","year":"2001","journal-title":"J Hosp Infect"},{"key":"2023063011203291300_znac053-B4","volume-title":"Surgical Site Infections: Prevention and Treatment","author":"National Institute for Health and Care Excellence"},{"key":"2023063011203291300_znac053-B5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajic.2015.02.012","article-title":"Procedure-specific surgical site infection incidence varies widely within certain National Healthcare Safety Network surgery groups","volume":"43","author":"Saeed","year":"2015","journal-title":"Am J Infect Control"},{"key":"2023063011203291300_znac053-B6","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.avsg.2014.06.055","article-title":"A survey of perioperative management of major lower limb amputations: current UK practice","volume":"28","author":"Barnes","year":"2014","journal-title":"Ann Vasc Surg"},{"key":"2023063011203291300_znac053-B7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3109\/17453679008993563","article-title":"Short-term cefotaxime prophylaxis reduces the failure rate in lower limb amputations","volume":"61","author":"Norlin","year":"1990","journal-title":"Acta Orthop Scand"},{"key":"2023063011203291300_znac053-B8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/BF00439382","article-title":"Antibiotic prophylaxis in lower-extremity amputations due to ischemia. 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