{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:33:18Z","timestamp":1774870398492,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"crossref"}]},{"name":"S\u00f6dersjukhuset Vascular Research Group"},{"DOI":"10.13039\/100018870","name":"Swedish Heart and Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023299","name":"Sophiahemmet Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100023299","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Management of intermittent claudication should include secondary prevention to reduce the risk of cardiocerebrovascular disease. Patient adherence to secondary prevention is a challenge. The aim of this study was to investigate whether a person-centred, nurse-led follow-up programme could improve adherence to medication compared with standard care.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A non-blinded RCT was conducted at two vascular surgery centres in Sweden. Patients with intermittent claudication and scheduled for revascularization were randomized to the intervention or control (standard care) follow-up programme. The primary outcome, adherence to prescribed secondary preventive medication, was based on registry data on dispensed medication and self-reported intake of medication. Secondary outcomes were risk factors for cardiocerebrovascular disease according to the Framingham risk score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Some 214 patients were randomized and analysed on an intention-to-treat basis. The mean proportion of days covered (PDC) at 1 year for lipid-modifying agents was 79 per cent in the intervention and 82 per cent in the control group, whereas it was 92 versus 91 per cent for antiplatelet and\/or anticoagulant agents. The groups did not differ in mean PDC (lipid-modifying P\u2009=\u20090.464; antiplatelets and\/or anticoagulants P\u2009=\u20090.700) or in change in adherence over time. Self-reported adherence to prescribed medication was higher than registry-based adherence regardless of allocation or medication group (minimum P\u2009&amp;lt;\u20090.001, maximum P\u2009=\u20090.034). There was no difference in median Framingham risk score at 1 year between the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with the standard follow-up programme, a person-centred, nurse-led follow-up programme did not improve adherence to secondary preventive medication. Adherence was overestimated when self-reported compared with registry-reported.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bjs\/znac241","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T11:19:07Z","timestamp":1664968747000},"page":"846-856","source":"Crossref","is-referenced-by-count":15,"title":["Effects of a person-centred, nurse-led follow-up programme on adherence to prescribed medication among patients surgically treated for intermittent claudication: randomized clinical trial"],"prefix":"10.1093","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-2585","authenticated-orcid":false,"given":"Sara T","family":"Haile","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Surgery, Section of Vascular Surgery, S\u00f6dersjukhuset , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-2468","authenticated-orcid":false,"given":"Eva","family":"Joelsson-Alm","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Anaesthesiology and Intensive Care, S\u00f6dersjukhuset , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unn Britt","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Health Promoting Science Sophiahemmet University , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"L\u00f6\u00f6f","sequence":"additional","affiliation":[{"name":"Department of Health Promoting Science Sophiahemmet University , Stockholm , Sweden"},{"name":"Division of Caring Sciences, School of Healthcare and Social Welfare, M\u00e4lardalen University , V\u00e4ster\u00e5s , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Palmer-Kazen","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Vascular surgery, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gillgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Surgery, Section of Vascular Surgery, S\u00f6dersjukhuset , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneli","family":"Linn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Surgery, Section of Vascular Surgery, S\u00f6dersjukhuset , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"2023063011092537400_znac241-B1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.recesp.2017.12.015","article-title":"2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS)","volume":"71","author":"Aboyans","year":"2018","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2023063011092537400_znac241-B2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ccd.21401","article-title":"Optimal risk factor modification and medical management of the patient with peripheral arterial disease","volume":"71","author":"Chi","year":"2008","journal-title":"Catheter Cardiovasc Interv"},{"key":"2023063011092537400_znac241-B3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/01.ATV.19.3.538","article-title":"Ankle\u2013arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. 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