{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:59:19Z","timestamp":1783403959924,"version":"3.54.6"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Bursectomy, the total resection of the bursa omentalis, is a standard procedure in gastrectomy for resectable gastric cancer. A phase III trial (JCOG1001) comparing bursectomy and omentectomy alone was terminated early at the interim analysis. The final results of the updated analysis after a minimum follow-up of 5 years are reported here.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with histologically proven adenocarcinoma of the stomach (cT3\u2013T4a) were randomized (1 : 1) during surgery to bursectomy or omentectomy-alone groups and then underwent D2 gastrectomy. The primary endpoint was overall survival, analysed on an intention-to-treat basis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 1204 patients (602 bursectomy and 602 omentectomy alone) were enrolled between June 2010 and March 2015. The bursectomy group had a significantly higher incidence of Clavien\u2013Dindo grade III\u2013IV intra-abdominal abscess than the omentectomy-alone group (5.5 versus 2.5 per cent respectively; P = 0.008). The updated 5-year overall survival rates were 74.9 (95 per cent c.i. 71.2 to 78.2) per cent in the bursectomy group and 76.5 (72.8 to 79.7) per cent in the omentectomy-alone group; the adjusted HR for death in the bursectomy group was 1.03 (95 per cent c.i. 0.83 to 1.27) (1-sided P = 0.598). Bursectomy did not decrease peritoneal recurrence (12.1 versus 12.3 per cent respectively; P = 1.000). In a multivariable analysis, old age (above 65 years), tumour located in the lower third or posterior wall of the stomach, macroscopic type 3\/5, total gastrectomy, and cT4a were independent predictors of poor overall survival, but omentectomy alone was not.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In D2 gastrectomy, bursectomy is not recommended as a standard procedure for cT3\u2013T4a gastric cancer. Registration number: UMIN000003688 (https:\/\/www.umin.ac.jp\/ctr\/).<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bjs\/znac373","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T09:39:04Z","timestamp":1668245944000},"page":"50-56","source":"Crossref","is-referenced-by-count":17,"title":["Five-year follow-up of a randomized clinical trial comparing bursectomy and omentectomy alone for resectable gastric cancer (JCOG1001)"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-0132","authenticated-orcid":false,"given":"Yukinori","family":"Kurokawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-5298","authenticated-orcid":false,"given":"Junki","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Centre\/Operations Office, National Cancer Centre Hospital , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery, National Cancer Centre Hospital , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Kanagawa Cancer Centre , Yokohama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sakai City Medical Centre , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science , Nagoya , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keiyukai Sapporo Hospital , Sapporo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yamagata Prefectural Central Hospital , Yamagata , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-1272","authenticated-orcid":false,"given":"Haruhiko","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Centre Komagome Hospital , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Surgery, Toyama Prefectural Central Hospital , Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Hirao","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Hospital Organization Osaka National Hospital , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Sasako","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yodogawa Christian Hospital , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-8267","authenticated-orcid":false,"given":"Masanori","family":"Terashima","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery, Shizuoka Cancer Centre , Mishima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,12]]},"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/110\/1\/50\/50749240\/znac373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/110\/1\/50\/50749240\/znac373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T10:59:13Z","timestamp":1688122753000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/110\/1\/50\/6825225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,11,12]]},"published-print":{"date-parts":[[2022,12,13]]}},"URL":"https:\/\/doi.org\/10.1093\/bjs\/znac373","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,12]]}}}